{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T10:10:51Z","timestamp":1784542251575,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,11,28]],"date-time":"2017-11-28T00:00:00Z","timestamp":1511827200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK104273"],"award-info":[{"award-number":["DK104273"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK102325"],"award-info":[{"award-number":["DK102325"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DK73608"],"award-info":[{"award-number":["DK73608"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL123160"],"award-info":[{"award-number":["HL123160"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Dynamic manganese\u2010enhanced MRI (MEMRI) allows assessment of tissue viability by tracing manganese uptake. We aimed to develop a rapid T<jats:sub>1<\/jats:sub> mapping method for dynamic MEMRI to facilitate assessments of murine kidney viability.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A multi\u2010slice saturation recovery fast spin echo (MSRFSE) was developed, validated, and subsequently applied in dynamic MEMRI at 16.4T on ischemic mouse kidneys after 4 weeks of unilateral renal artery stenosis (RAS). Baseline T<jats:sub>1<\/jats:sub> values and post\u2010contrast R<jats:sub>1<\/jats:sub> (1\/T<jats:sub>1<\/jats:sub>) changes were measured in cortex (CO), outer (OSOM), inner (ISOM) strips of outer medulla, and inner medulla (IM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Validation studies showed strong agreement between MSRFSE and an established saturation recovery Look\u2010Locker method. Baseline T<jats:sub>1<\/jats:sub> (s) increased in the stenotic kidney CO (2.10 [1.95\u20132.56] vs. 1.88 [1.81\u20132.00], <jats:italic>P<\/jats:italic>\u2009=\u20090.0317) and OSOM (2.17 [2.05\u20132.33] vs. 1.96 [1.87\u20132.00], <jats:italic>P<\/jats:italic>\u2009=\u20090.0075) but remained unchanged in ISOM and IM. This method allowed a temporal resolution of 1.43\u2009min in dynamic MEMRI. Mn<jats:sup>2+<\/jats:sup> uptake and retention decreased in stenotic kidneys, particularly in the OSOM (\u0394R<jats:sub>1<\/jats:sub>: 0.48 [0.38\u20130.56] vs. 0.64 [0.61\u20130.69] s<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dynamic MEMRI by MSRFSE detected decreased cellular viability and discerned the regional responses to RAS. This technique may provide a valuable tool for noninvasive evaluation of renal viability. Magn Reson Med 80:190\u2013199, 2018. \u00a9 2017 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.27025","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:24:08Z","timestamp":1511976248000},"page":"190-199","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["A rapid T<sub>1<\/sub> mapping method for assessment of murine kidney viability using dynamic manganese\u2010enhanced magnetic resonance imaging"],"prefix":"10.1002","volume":"80","author":[{"given":"Kai","family":"Jiang","sequence":"first","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Tang","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prasanna K.","family":"Mishra","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology, Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Slobodan I.","family":"Macura","sequence":"additional","affiliation":[{"name":"Biochemistry and Molecular Biology, Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lilach O.","family":"Lerman","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Hypertension, Mayo Clinic Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.945"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2011.07.076"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(87)90485-1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.817"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.943"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.rli.0000153025.72638.63"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1414"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.115.002044"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21065"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.90336.2008"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22071"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-198409000-00012"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1273"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1287"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2799"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25533"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20797"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22544"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2016.11.004"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25175"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2016160566"},{"key":"e_1_2_5_23_1","first-page":"395","volume-title":"Nuclear magnetic resonance (N.M.R.) in biochemistry: applications to enzyme systems","author":"Dwek RA","year":"1975"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b10748"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.933"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-201X.1997.d01-841.x"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40572-015-0056-x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21504"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-2888-2_42"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000256155.31133.49"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2009.04.002"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2mt20024d"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.trsl.2017.03.002"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.47.5.721"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1997.50"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/1741-7015-9-11"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.2002.00631.x"},{"key":"e_1_2_5_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1978.87"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00050.2001"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20500"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.27025","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.27025","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:44:26Z","timestamp":1695570266000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.27025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,28]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,7]]}},"alternative-id":["10.1002\/mrm.27025"],"URL":"https:\/\/doi.org\/10.1002\/mrm.27025","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,11,28]]},"assertion":[{"value":"2017-07-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-11-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}