{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T22:32:01Z","timestamp":1788474721892,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,15]],"date-time":"2018-01-15T00:00:00Z","timestamp":1515974400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"the European Social Fund and national funds","award":["NSRF 2007-2013"],"award-info":[{"award-number":["NSRF 2007-2013"]}]},{"name":"the Horizon 2020 CDS-QUAMRI grant","award":["634541"],"award-info":[{"award-number":["634541"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Macromolecular resonances (MM) arise mainly from cytosolic proteins and overlap with metabolites, influencing metabolite quantification. Macromolecules can serve as valuable biomarkers for diseases and pathologies. The objectives of this study were to characterize MM at 9.4T in the human brain (occipital and left parietal lobe) and to describe the RF coil setup used for MM acquisition in the two regions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An adiabatic inversion pulse was optimised for metabolite nulling at 9.4T using double inversion recovery and was combined for the first time with metabolite cycled (MC) semi\u2010LASER and appropriate coil configuration. MM spectra (seven volunteers) from two brain locations were averaged and smoothed creating MM templates, which were then parametrized using simulated Voigt\u2010shaped lines within LCModel. Quantification was performed on individual data sets, including corrections for different tissue composition and the T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> relaxation of water.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our coil configuration method resulted in efficient \n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm27070-math-0001.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm27070:mrm27070-math-0001\"\/> (&gt;30\u2009T\/\u221akW) for both brain regions. The 15\u2009MM components were detected and quantified in MM baselines of the two brain areas. No significant differences in concentration levels of MM between different regions were found. Two new MM peaks were reported (M7 &amp; M8).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Double inversion, which was combined with MC semi\u2010LASER, enabled the acquisition of high spectral resolution MM spectra for both brain regions at 9.4T. The 15\u2009MM components were detected and quantified. Two new MM peaks were reported for the first time (M7 &amp; M8) and preliminarily assigned to \u03b2\u2010methylene protons of aspartyl\u2010groups. 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