{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T14:31:43Z","timestamp":1777991503718,"version":"3.51.4"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>4D dynamic MR angiography (4D\u2010MRA) using pseudo\u2010continuous arterial spin labeling (pCASL), combined with Keyhole and View\u2010sharing (4D\u2010PACK) for scan acceleration, is introduced. Its validity for arterial inflow dynamics visualization was investigated through comparison with 4D\u2010pCASL and contrast inherent inflow enhanced multiphase angiography (CINEMA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six healthy volunteers were included in the study. The arterial transit time (ATT) in 4D\u2010PACK was measured at multiple regions in middle cerebral artery (MCA), and Pearson's correlation coefficient with ATT in 4D\u2010pCASL was calculated. The contrast\u2010to\u2010noise ratio (CNR) in 4D\u2010PACK was measured in four MCA segments and compared with that in 4D\u2010pCASL and CINEMA. Arterial visualization in 4D\u2010PACK was assessed qualitatively in patients with moyamoya disease and arteriovenous malformation by comparing with CINEMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>4D\u2010PACK achieved a 36% scan time reduction compared with 4D\u2010pCASL. The correlation coefficient for ATT measured by 4D\u2010pCASL and 4D\u2010PACK was greater than 0.96. The CNR was significantly higher using 4D\u2010PACK compared with CINEMA in the M4 segment (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). In patient examinations, the flow in the collateral artery or draining vein was better visualized in 4D\u2010PACK compared with CINEMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>4D\u2010PACK accelerates 4D\u2010pCASL, shows similar inflow dynamics as 4D\u2010pCASL and shows better peripheral visualization compared with CINEMA. Magn Reson Med 80:719\u2013725, 2018. \u00a9 2018 International Society for Magnetic Resonance in Medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.27074","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T12:38:48Z","timestamp":1516883928000},"page":"719-725","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Non\u2010contrast enhanced 4D intracranial MR angiography based on pseudo\u2010continuous arterial spin labeling with the keyhole and view\u2010sharing technique"],"prefix":"10.1002","volume":"80","author":[{"given":"Makoto","family":"Obara","sequence":"first","affiliation":[{"name":"Philips Electronics Japan Ltd., Healthcare Shinagawa Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Togao","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology Graduate School of Medical Sciences, Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele M.","family":"Beck","sequence":"additional","affiliation":[{"name":"Philips Healthcare, Best  The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Shibukawa","sequence":"additional","affiliation":[{"name":"Department of Radiology Tokai University Hospital Isehara Kanagawa Japan"},{"name":"Division of Health Sciences Graduate School of Medical Sciences, Kanazawa University Kanazawa Ishikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyuki","family":"Okuaki","sequence":"additional","affiliation":[{"name":"Division of Health Sciences Graduate School of Medical Sciences, Kanazawa University Kanazawa Ishikawa Japan"},{"name":"Philips Healthcare, Asia Pacific Shinagawa Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"Yoneyama","sequence":"additional","affiliation":[{"name":"Philips Electronics Japan Ltd., Healthcare Shinagawa Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Philips Electronics Japan Ltd., Healthcare Shinagawa Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Clinical Radiology Graduate School of Medical Sciences, Kyushu University Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9654-1746","authenticated-orcid":false,"given":"Marc","family":"Van Cauteren","sequence":"additional","affiliation":[{"name":"Philips Healthcare, Asia Pacific Shinagawa Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000346"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3515"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25222"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.03.001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2015.07.003"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2015.05.002"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24279"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122670"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2012.02.027"},{"key":"e_1_2_6_11_1","unstructured":"NakamuraM YoneyamaM OkuakiT TabuchiT TakemuraA ObaraM OguraJ TsutsumiS.Non contrast 3D volumetric time\u2010resolved MRA combining multiple phase fair (CINEMA\u2010fair). 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