{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:01:48Z","timestamp":1787065308001,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EB016045"],"award-info":[{"award-number":["R01EB016045"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR060238"],"award-info":[{"award-number":["R01\u2010AR060238"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR067156"],"award-info":[{"award-number":["R01\u2010AR067156"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AR068966"],"award-info":[{"award-number":["R01\u2010AR068966"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To investigate the effect of a frequency drift of the static magnetic field on 3D CEST MRI based on glycosaminoglycans (GAGs) of articular cartilage at 7\u2009T and to introduce a retrospective correction method that uses the phase images of the gradient\u2010echo readout.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Repeated gagCEST and B\n                      <jats:sub>0<\/jats:sub>\n                      measurements were performed in a glucose model solution and in vivo in the knee joint of 3 healthy volunteers at 7\u2009T. Phase images of the modified 3D rectangular spiral centric\u2013reordered gradient\u2010echo CEST sequence were used to quantify and compensate the apparent frequency drift in repeated gagCEST measurements.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The frequency drift of the MRI scanner strongly influences the gagCEST signal in the articular cartilage of the human knee joint. The gagCEST signal in the articular cartilage is changed by 0.18%\/Hz while an average drift of 0.7\u2009\u00b1\u20090.2\u2009Hz\/minute was observed. The proposed correction method can be applied retrospectively without the need of additional measurements and provides improved comparability and reproducibility for gagCEST studies. This correction method may also be of interest for other applications of CEST MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prospective or retrospective correction of the frequency drift of the MRI scanner is essential for reproducible gagCEST measurements. The proposed retrospective correction method fulfills this requirement without the need of additional measurements.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.27367","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T07:55:04Z","timestamp":1527753304000},"page":"573-582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Assessment of frequency drift on CEST MRI and dynamic correction: application to gagCEST at 7 T"],"prefix":"10.1002","volume":"81","author":[{"given":"Johannes","family":"Windschuh","sequence":"first","affiliation":[{"name":"New York University Langone Medical Center, Department of Radiology, Center for Biomedical Imaging  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moritz","family":"Zaiss","sequence":"additional","affiliation":[{"name":"Max Planck Institute for Biological Cybernetics High\u2010Field Magnetic Resonance Center  T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp","family":"Ehses","sequence":"additional","affiliation":[{"name":"German Center for Neurodegenerative Diseases, Department of MR Physics  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-0663","authenticated-orcid":false,"given":"Jae\u2010Seung","family":"Lee","sequence":"additional","affiliation":[{"name":"New York University Langone Medical Center, Department of Radiology, Center for Biomedical Imaging  New York New York"},{"name":"New York University, Department of Chemistry  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexej","family":"Jerschow","sequence":"additional","affiliation":[{"name":"New York University, Department of Chemistry  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder R.","family":"Regatte","sequence":"additional","affiliation":[{"name":"New York University Langone Medical Center, Department of Radiology, Center for Biomedical Imaging  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(90)90220-4"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1956"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm907"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3252"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2615"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0707666105"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11101841"},{"key":"e_1_2_7_9_1","first-page":"207","volume-title":"Advances in MRI of the knee for osteoarthritis","author":"Blumenfeld J","year":"2010"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1063"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2003.11.003"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.36.2.121"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/22\/R221"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470034590.emrstm1482"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.240"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.04.045"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21873"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26133"},{"key":"e_1_2_7_19_1","unstructured":"KeuppJ EggersH.CEST\u2010Dixon MRI for sensitive and accurate measurement of amide proton transfer in humans at 3T. 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