{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T18:04:26Z","timestamp":1790791466677,"version":"4.1.0"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T00:00:00Z","timestamp":1537488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["210182\/Z\/18\/Z"],"award-info":[{"award-number":["210182\/Z\/18\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["101957\/Z\/13\/Z"],"award-info":[{"award-number":["101957\/Z\/13\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["NS\/A000027\/1"],"award-info":[{"award-number":["NS\/A000027\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/L016478\/1"],"award-info":[{"award-number":["EP\/L016478\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2019,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The placenta is a vital organ for the exchange of oxygen, nutrients, and waste products between fetus and mother. The placenta may suffer from several pathologies, which affect this fetal\u2010maternal exchange, thus the flow properties of the placenta are of interest in determining the course of pregnancy. In this work, we propose a new multiparametric model for placental tissue signal in MRI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We describe a method that separates fetal and maternal flow characteristics of the placenta using a 3\u2010compartment model comprising fast and slowly circulating fluid pools, and a tissue pool is fitted to overlapping multiecho T2 relaxometry and diffusion MRI with low b\u2010values. We implemented the combined model and acquisition on a standard 1.5 Tesla clinical system with acquisition taking less than 20 minutes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We apply this combined acquisition in 6 control singleton placentas. Mean myometrial T2 relaxation time was 123.63 (\u00b16.71) ms. Mean T2 relaxation time of maternal blood was 202.17 (\u00b192.98) ms. In the placenta, mean T2 relaxation time of the fetal blood component was 144.89 (\u00b154.42) ms. Mean ratio of maternal to fetal blood volume was 1.16 (\u00b10.6), and mean fetal blood saturation was 72.93 (\u00b120.11)% across all 6 cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The novel acquisition in this work allows the measurement of histologically relevant physical parameters, such as the relative proportions of vascular spaces. In the placenta, this may help us to better understand the physiological properties of the tissue in disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.27406","type":"journal-article","created":{"date-parts":[[2018,9,21]],"date-time":"2018-09-21T19:16:37Z","timestamp":1537557397000},"page":"350-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":78,"title":["Separating fetal and maternal placenta circulations using multiparametric MRI"],"prefix":"10.1002","volume":"81","author":[{"given":"Andrew","family":"Melbourne","sequence":"first","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"},{"name":"School of Biomedical Engineering and Imaging Kings College London, London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalind","family":"Aughwane","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"},{"name":"Institute for Women\u2019s Health University College Hospital,London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Sokolska","sequence":"additional","affiliation":[{"name":"Medical Physics University College Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5381-7722","authenticated-orcid":false,"given":"David","family":"Owen","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"},{"name":"School of Biomedical Engineering and Imaging Kings College London, London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Kendall","sequence":"additional","affiliation":[{"name":"Institute for Women\u2019s Health University College Hospital,London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Flouri","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"},{"name":"School of Biomedical Engineering and Imaging Kings College London, London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Bainbridge","sequence":"additional","affiliation":[{"name":"Medical Physics University College Hospital London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1124-6666","authenticated-orcid":false,"given":"David","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Centre for Medical Imaging University College London London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Deprest","sequence":"additional","affiliation":[{"name":"Institute for Women\u2019s Health University College Hospital,London London United Kingdom"},{"name":"University Hospital KU Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Vercauteren","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"},{"name":"School of Biomedical Engineering and Imaging Kings College London, London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"David","sequence":"additional","affiliation":[{"name":"Institute for Women\u2019s Health University College Hospital,London London United Kingdom"},{"name":"University Hospital KU Leuven Leuven Belgium"},{"name":"NIHR University College London Hospitals Biomedical Research Centre London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Ourselin","sequence":"additional","affiliation":[{"name":"Department of Medical Physics and Biomedical Engineering University College London London United Kingdom"},{"name":"School of Biomedical Engineering and Imaging Kings College London, London United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0306-3356(21)00030-3","article-title":"Pathology of the placenta","volume":"13","author":"Fox H","year":"1986","journal-title":"Clin Obstet Gynaecol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2009.173252"},{"issue":"514","key":"e_1_2_7_4_1","first-page":"e1","article-title":"The outcome of monochorionic diamniotic twin gestations in the era of invasive fetal therapy: a prospective cohort study","volume":"199","author":"Lewi L","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.04.007"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4401"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2009.02.009"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1542\/neo.9-9-e393"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2005.05.001"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2010.09.001"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.06.045"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26052"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25264"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.12126"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27100"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25893"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/61\/24\/N667"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25245"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.07.006"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27036"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24581"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12582"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.11.002"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.11.009"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.03.005"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20605"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2016.01.016"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25775"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2016.10.001"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.07.216"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/52\/17\/003"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2009.09.002"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2303021331"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-6576.1995.tb04347.x"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26231"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1054\/mehy.2001.1538"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.27406","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.27406","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T10:58:48Z","timestamp":1694343528000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.27406"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,21]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["10.1002\/mrm.27406"],"URL":"https:\/\/doi.org\/10.1002\/mrm.27406","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,21]]},"assertion":[{"value":"2018-03-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}