{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T06:25:15Z","timestamp":1791699915162,"version":"4.3.4"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,5,12]],"date-time":"2019-05-12T00:00:00Z","timestamp":1557619200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000266","name":"Engineering and Physical Sciences Research Council","doi-asserted-by":"publisher","award":["EP\/H046410\/1"],"award-info":[{"award-number":["EP\/H046410\/1"]}],"id":[{"id":"10.13039\/501100000266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop an MRI acquisition and reconstruction framework for volumetric cine visualization of the fetal heart and great vessels in the presence of maternal and fetal motion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Four\u2010dimensional (4D) depiction was achieved using a highly\u2010accelerated multi\u2010planar real\u2010time balanced steady\u2010state free precession acquisition combined with retrospective image\u2010domain techniques for motion correction, cardiac synchronization and outlier rejection. The framework was validated using a numerical phantom and evaluated in a study of 20 mid\u2010 to late\u2010gestational age human fetal subjects (23\u201033 weeks gestational age). Reconstructed MR data were compared with matched ultrasound. A preliminary assessment of flow\u2010sensitive reconstruction using the velocity information encoded in the phase of real\u2010time images is included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reconstructed 4D data could be visualized in any two\u2010dimensional plane without the need for highly specific scan plane prescription prior to acquisition or for maternal breath hold to minimize motion. Reconstruction was fully automated aside from user\u2010specified masks of the fetal heart and chest. The framework proved robust when applied to fetal data and simulations confirmed that spatial and temporal features could be reliably recovered. Evaluation suggested the reconstructed framework has the potential to be used for comprehensive assessment of the fetal heart, either as an adjunct to ultrasound or in combination with other MRI techniques.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The proposed methods show promise as a framework for motion\u2010compensated 4D assessment of the fetal heart and great vessels.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.27798","type":"journal-article","created":{"date-parts":[[2019,5,13]],"date-time":"2019-05-13T06:18:35Z","timestamp":1557728315000},"page":"1055-1072","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Fetal whole\u2010heart 4D imaging using motion\u2010corrected multi\u2010planar real\u2010time MRI"],"prefix":"10.1002","volume":"82","author":[{"given":"Joshua F.P.","family":"van Amerom","sequence":"first","affiliation":[{"name":"School of Biomedical Engineering &amp; 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