{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T02:08:41Z","timestamp":1788401321908,"version":"build-2803163510"},"reference-count":87,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To evaluate different T<jats:sub>2<\/jats:sub>\u2010oxygenation calibrations for estimating venous oxygenation in people with sickle cell anemia (SCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Blood T<jats:sub>2<\/jats:sub> values were measured at 3 T in the internal jugular veins of 12 healthy volunteers and 11 SCA participants with no history of stroke, recent transfusion, or renal impairment. T<jats:sub>2<\/jats:sub>\u2010oxygenation relationships of both sickled and normal blood samples were calibrated individually and compared with values generated from published models. After converting venous T<jats:sub>2<\/jats:sub> values to venous oxygenation, whole\u2010brain oxygen extraction fraction and cerebral metabolic rate of oxygen were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sickle blood samples' oxygenation values calculated from our individual calibrations agreed well with measurements using a blood analyzer, whereas previous T<jats:sub>2<\/jats:sub> calibrations based on normal blood samples showed 13%\u201019% underestimation. Meanwhile, oxygenation values calculated from previous grouped T<jats:sub>2<\/jats:sub> calibration for sickle blood agreed well with experimental measurement on averaged values, but showed up to 20% variation for several individual samples. Using individual T<jats:sub>2<\/jats:sub> calibrations, the whole\u2010brain oxygen extraction fraction and cerebral metabolic rate of oxygen of SCA participants were 0.38 \u00b1 0.08 and 172 \u00b1 42 \u00b5mol\/min\/100 g, respectively, which were comparable to those values measured on healthy volunteers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results confirm that sickle blood T<jats:sub>2<\/jats:sub> values not only depend on the hematocrit and oxygenation values, but also on other hematological factors. The individual T<jats:sub>2<\/jats:sub> calibrations minimized the effect of heterogeneity of sickle blood between different SCA populations and improved the accuracy of T<jats:sub>2<\/jats:sub>\u2010based oximetry. The measured oxygen extraction fraction and cerebral metabolic rate of oxygen of this group of SCA participants were found to not differ significantly from those of healthy individuals.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.27972","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T15:47:46Z","timestamp":1567612066000},"page":"1066-1080","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":33,"title":["Quantification of whole\u2010brain oxygenation extraction fraction and cerebral metabolic rate of oxygen consumption in adults with sickle cell anemia using individual T<sub>2<\/sub>\u2010based oxygenation calibrations"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0199-1534","authenticated-orcid":false,"given":"Wenbo","family":"Li","sequence":"first","affiliation":[{"name":"Russell H. 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