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Existing dehydration diagnostics require invasive bodily fluid sampling or are easily confounded by fluid and electrolyte intake, environment, and physical activity limiting widespread adoption. We present a portable MR sensor designed to measure intramuscular fluid shifts to identify volume depletion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fluid loss is induced via a mouse model of thermal dehydration (37\u00b0C; 15\u201020% relative humidity). We demonstrate quantification of fluid loss induced by hyperosmotic dehydration with multicomponent T2 relaxometry using both a benchtop NMR system and MRI localized to skeletal muscle tissue. We then describe a miniaturized (~1000 cm<jats:sup>3<\/jats:sup>) portable (~4 kg) MR sensor (0.28\u00a0T) designed to identify dehydration\u2010induced fluid loss. T2 relaxometry measurements were performed using a Carr\u2010Purcell\u2010Meiboom\u2010Gill pulse sequence in ~4 min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>T2 values from the portable MR sensor exhibited strong (R<jats:sup>2<\/jats:sup> = 0.996) agreement with benchtop NMR spectrometer. Thermal dehydration induced weight loss of 4 to 11% over 5 to 10 h. Fluid loss induced by thermal dehydration was accurately identified via whole\u2010animal NMR and skeletal muscle. The portable MR sensor accurately identified dehydration via multicomponent T2 relaxometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Performing multicomponent T2 relaxometry localized to the skeletal muscle with a miniaturized MR sensor provides a noninvasive, physiologically relevant measure of dehydration induced fluid loss in a mouse model. This approach offers sensor portability, reduced system complexity, fully automated operation, and low cost compared with MRI. This approach may serve as a versatile and portable point of care technique for dehydration monitoring.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28004","type":"journal-article","created":{"date-parts":[[2019,10,21]],"date-time":"2019-10-21T07:44:57Z","timestamp":1571643897000},"page":"1390-1404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Dehydration assessment via a portable, single sided magnetic resonance sensor"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0541-5080","authenticated-orcid":false,"given":"Ashvin","family":"Bashyam","sequence":"first","affiliation":[{"name":"David H. 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