{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:01:44Z","timestamp":1790654504156,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T00:00:00Z","timestamp":1571961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR\u201017\u2010CE19\u20100002\u201001"],"award-info":[{"award-number":["ANR\u201017\u2010CE19\u20100002\u201001"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The objective of this study is to evaluate the suitability and performance of ultra\u2010short echo time (UTE) sequences for imaging and quantifying the deposition of nebulized MRI contrast agents in human\u2010sized lungs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Nebulization of clinically used contrast agent or gadolinium\u2010based nanoparticles were performed using a commercial jet nebulizer in isolated and ventilated porcine lungs connected to a 3D\u2010printed human upper airways replica. MR images of isolated lungs were acquired on a 3T clinical MR scanner using 3D UTE sequences at different flip angles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>3D acquisitions with isotropic millimetric resolution were obtained in less than 4 min. Images exhibit homogeneous and large MR signal enhancement (above 200%) following nebulization of both types of aerosols. Deposition of aerosol down to the level of the bronchi of secondary lobules was visualized. T<jats:sub>1<\/jats:sub> values and the concentration of nanoparticles obtained by MRI were found to correlate with the amount of nebulized gadolinium<jats:sup>3+<\/jats:sup> ions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The distribution of aerosolized gadolinium\u2010based contrast agent or nanoparticles can be visualized and quantified using UTE MRI in large animal ventilated lung model on a clinical MRI scanner. This protocol can be used for assessing and quantifying aerosol regional deposition with high spatial resolution (1 mm 3D isotropic) without ionizing radiation and could be applied in the future for diagnostic or therapeutic applications in patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28041","type":"journal-article","created":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T05:30:14Z","timestamp":1572067814000},"page":"1774-1782","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Three\u2010dimensional quantitative MRI of aerosolized gadolinium\u2010based nanoparticles and contrast agents in isolated ventilated porcine lungs"],"prefix":"10.1002","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3262-5983","authenticated-orcid":false,"given":"Yannick","family":"Cr\u00e9millieux","sequence":"first","affiliation":[{"name":"Institut des Sciences Mol\u00e9culaires Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoann","family":"Montigaud","sequence":"additional","affiliation":[{"name":"Mines Saint\u2010Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e9mence","family":"Bal","sequence":"additional","affiliation":[{"name":"IBIO Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"No\u00ebl","family":"Pinaud","sequence":"additional","affiliation":[{"name":"Institut des Sciences Mol\u00e9culaires Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vi","family":"Pham","sequence":"additional","affiliation":[{"name":"Institut des Sciences Mol\u00e9culaires Universit\u00e9 de Bordeaux Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Perinel","sequence":"additional","affiliation":[{"name":"INSERM U 1059 Sainbiose Universit\u00e9 Jean Monnet Saint\u2010Etienne France"},{"name":"CHU Saint\u2010Etienne Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Natuzzi","sequence":"additional","affiliation":[{"name":"Institut Lumi\u00e8re Mati\u00e8re UMR5306 Universit\u00e9 Lyon1-CNRS Universit\u00e9 de Lyon Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Lux","sequence":"additional","affiliation":[{"name":"Institut Lumi\u00e8re Mati\u00e8re UMR5306 Universit\u00e9 Lyon1-CNRS Universit\u00e9 de Lyon Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Tillement","sequence":"additional","affiliation":[{"name":"Institut Lumi\u00e8re Mati\u00e8re UMR5306 Universit\u00e9 Lyon1-CNRS Universit\u00e9 de Lyon Villeurbanne France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyasu","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Canon Medical Systems Corporation Otawara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Canon Medical Systems Europe Zoetermeer Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00e9mie","family":"Pourchez","sequence":"additional","affiliation":[{"name":"Mines Saint\u2010Etienne, Univ Lyon, Univ Jean Monnet, INSERM, U 1059 Sainbiose, Centre CIS Saint\u2010Etienne France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,25]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.183.3.1584916"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-200502000-00005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181761841"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.252"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4013"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3790"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmmi.1703"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1402196111"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201401284"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/08942680152484108"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1089\/jamp.2010.0845"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24570"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22521"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24429"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25309"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910280209"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.179.3.2027991"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24580"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-013-0412-5"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0395-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43121"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201104104"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910320105"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20180365"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2015142690"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmrm.28041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.28041","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.28041","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.28041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T21:36:05Z","timestamp":1694122565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.28041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,25]]},"references-count":25,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/mrm.28041"],"URL":"https:\/\/doi.org\/10.1002\/mrm.28041","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,25]]},"assertion":[{"value":"2019-07-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}