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Quantification of systolic aortic peak velocity, helicity, and 3D\u2010WSS distribution and the calculation of age group\u2013averaged peak systolic velocity and 3D\u2010WSS maps (\u201catlases\u201d) were computed. Age\u2010related and sex\u2010related changes in peak velocity, helicity, and 3D\u2010WSS were computed and correlated with standard metrics of left ventricular function derived from short\u2010axis cine MRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No significant differences were found in peak systolic velocity or 3D\u2010WSS based on sex except for the 18\u2010 to 30\u2010year\u2010old group (males 8% higher velocity volume and 3D\u2010WSS surface area). Between successively older groups, systolic velocity decreased (13%, &lt;1%, 7%, and 55% of the aorta volume) and 3D\u2010WSS decreased (21%, 2%, 30%, and 62% of the aorta surface area). Mean velocity, mean 3D\u20103D\u2010WSS, and median helicity increased with cardiac output (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.27\u20100.43, all <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), and mean velocity and 3D\u2010WSS decreased with increasing diameter (<jats:italic>r<\/jats:italic>\u00a0&gt;\u00a00.35, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Arch and descending aorta systolic mean velocity, mean 3D\u2010WSS, and median helicity increased with normalized left ventricular volumes: end diastolic volume (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.31\u20100.37, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), end systolic volume (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.27\u20100.35, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01), and stroke volume (<jats:italic>r<\/jats:italic>\u00a0=\u00a00.28\u20100.35, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Healthy aortic hemodynamics are dependent on subject age, and correlate with vessel diameter and cardiac function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28250","type":"journal-article","created":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T04:43:28Z","timestamp":1583988208000},"page":"2088-2102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Impact of age, sex, and global function on normal aortic hemodynamics"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7160-4248","authenticated-orcid":false,"given":"Michael B.","family":"Scott","sequence":"first","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University Chicago IL USA"},{"name":"Department of Biomedical Engineering McCormick School of Engineering Northwestern University Evanston IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyungkyu","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pim","family":"van Ooij","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine Academic Medical Centre Amsterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda","family":"Herrera","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Elbaz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"McCarthy","sequence":"additional","affiliation":[{"name":"Bluhm Cardiovascular Institute Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Division of Cardiac Surgery Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Chris","family":"Malaisrie","sequence":"additional","affiliation":[{"name":"Bluhm Cardiovascular Institute Northwestern University Feinberg School of Medicine Chicago IL USA"},{"name":"Division of Cardiac Surgery Northwestern University Feinberg School of Medicine Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Carr","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul W. 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