{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T23:36:21Z","timestamp":1780097781954,"version":"3.54.0"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T00:00:00Z","timestamp":1586476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["17\u201002\u201000465"],"award-info":[{"award-number":["17\u201002\u201000465"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002261","name":"Russian Foundation for Basic Research","doi-asserted-by":"publisher","award":["19\u201029\u201010015"],"award-info":[{"award-number":["19\u201029\u201010015"]}],"id":[{"id":"10.13039\/501100002261","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>The aim of this study was to demonstrate the feasibility of fluorine\u201019 (<jats:sup>19<\/jats:sup>F) MRI of the human lungs using octafluorocyclobutane (OFCB, C<jats:sub>4<\/jats:sub>F<jats:sub>8<\/jats:sub>). This gas has 8 magnetically equivalent fluorine nuclei and relatively long T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> (\u02dc50 ms), which render it suitable as an MRI contrast agent. Previous experiments in small laboratory animals showed that OFCB could be successfully used as an alternative to the gases often used for <jats:sup>19<\/jats:sup>F MRI (sulfur hexafluoride and perfluoropropane).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One male volunteer participated in this study. Immediately before an MRI scan, the volunteer inhaled the gas mixture\u201480% OFCB with 20% oxygen\u2014and held his breath. Experiments were performed on a 0.5T whole\u2010body MR scanner with a customized transmit\u2013receive coil tuned at <jats:sup>19<\/jats:sup>F frequency. Fast spin echo in 2D and 3D modes was used for image acquisition. 2D images were obtained with in\u2010plane resolution of 10 \u00d7 10 mm<jats:sup>2<\/jats:sup> without slice selection. 3D images were obtained with the voxel size of 10 \u00d7 10 \u00d7 30 mm<jats:sup>2<\/jats:sup>. Breath\u2010hold duration was 20 s for 2D and 40 s for 3D imaging, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Anatomically consistent <jats:sup>19<\/jats:sup>F MR images of the human lungs were obtained with SNR around 50 in 2D mode and 20 in 3D mode. 3D volumetric images of the lungs were reconstructed and provided physiologically reasonable volume estimates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The application of OFCB enables informative <jats:sup>19<\/jats:sup>F lung imaging even at low magnetic field strengths. The OFCB gas shows promise as an inhalable contrast agent for fluorine lung MRI and has a potential for clinical translation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28270","type":"journal-article","created":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T08:27:52Z","timestamp":1586507272000},"page":"2117-2123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["<sup>19<\/sup>F MRI of human lungs at 0.5 Tesla using octafluorocyclobutane"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2574-1978","authenticated-orcid":false,"given":"Olga S.","family":"Pavlova","sequence":"first","affiliation":[{"name":"Faculty of Physics Lomonosov Moscow State University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolay V.","family":"Anisimov","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine Lomonosov Moscow State University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lev L.","family":"Gervits","sequence":"additional","affiliation":[{"name":"Nesmeyanov Institute of Organoelement Compounds of the Russian Academy of Sciences Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4684-2484","authenticated-orcid":false,"given":"Mikhail V.","family":"Gulyaev","sequence":"additional","affiliation":[{"name":"Faculty of Fundamental Medicine Lomonosov Moscow State University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina N.","family":"Semenova","sequence":"additional","affiliation":[{"name":"Faculty of Physics Lomonosov Moscow State University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yury A.","family":"Pirogov","sequence":"additional","affiliation":[{"name":"Faculty of Physics Lomonosov Moscow State University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislav Ya.","family":"Panchenko","sequence":"additional","affiliation":[{"name":"Faculty of Physics Lomonosov Moscow State University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13244-011-0146-8"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24570"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22375"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.23844"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25002"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr500286d"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1570"},{"key":"e_1_2_7_9_1","unstructured":"HeidelbergerE LauterburPC.Gas phase 19F\u2010NMR zeugmatography: a new approach to lung ventilation imaging. 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