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We recently introduced the dynamic multicoil technique (DYNAMITE) for B<jats:sub>0<\/jats:sub> field control and demonstrated DYNAMITE MRI in a preclinical MR environment. In this study, we report the first realization of DYNAMITE MRI of the in vivo human head.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Gradient fields for DYNAMITE MRI were generated with a 28\u2010channel multicoil hardware arranged in 4 rows of 7 coils on a cylindrical surface (length 359\u00a0mm, diameter 344 mm, maximum 5\u00a0A per coil). DYNAMITE MRIs of a resolution phantom and in vivo human heads were acquired with multislice gradient\u2010echo, multislice spin\u2010echo, and 3D gradient\u2010echo sequences. The resultant image fidelity was compared to that obtained with conventional gradient coil technology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DYNAMITE field control enabled the realization of all imaging sequences with average gradient errors \u2264 1%. DYNAMITE MRI provided image quality and sensitivity comparable to conventional gradient technology without any obvious artifacts. Some minor geometric deformations were noticed primarily in the image periphery as the result of regional field imperfections. The imperfections can be readily approximated theoretically through numerical integration of the Biot\u2010Savart law and removed through image distortion correction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The first realization of DYNAMITE MRI of the in vivo human head has been presented. The obtained image fidelity is comparable to MRI with conventional gradient coils, paving the way for full\u2010fledged DYNAMITE MRI and B<jats:sub>0<\/jats:sub> shim systems for human applications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28323","type":"journal-article","created":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T19:59:28Z","timestamp":1592337568000},"page":"2953-2963","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Dynamic multicoil technique (DYNAMITE) MRI on human brain"],"prefix":"10.1002","volume":"84","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1505-201X","authenticated-orcid":false,"given":"Christoph","family":"Juchem","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Columbia University New York New York USA"},{"name":"Department of Radiology Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3439-5111","authenticated-orcid":false,"given":"Sebastian","family":"Theilenberg","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering Columbia University New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-7819","authenticated-orcid":false,"given":"Chathura","family":"Kumaragamage","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Magnetic Resonance Research Center Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-6413","authenticated-orcid":false,"given":"Michael","family":"Mullen","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lance","family":"DelaBarre","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Adriany","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter B.","family":"Brown","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Magnetic Resonance Research Center Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McIntyre","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Magnetic Resonance Research Center Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence W.","family":"Nixon","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Magnetic Resonance Research Center Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Garwood","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research University of Minnesota Medical School Minneapolis Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6570-7010","authenticated-orcid":false,"given":"Robin A.","family":"de Graaf","sequence":"additional","affiliation":[{"name":"Department of Radiology and Biomedical Imaging Magnetic Resonance Research Center Yale University School of Medicine New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(93)90209-V"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmr.b.20134"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","unstructured":"RoemerPB HickleyJS inventors; General Electric Co Milwaukee WI assignee.Self\u2010shielded gradient coils for nuclear magnetic resonance imaging. 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