{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T06:59:52Z","timestamp":1784617192704,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T00:00:00Z","timestamp":1605052800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["NIH T32 HL 007284"],"award-info":[{"award-number":["NIH T32 HL 007284"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006599","name":"Focused Ultrasound Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01 EB028773"],"award-info":[{"award-number":["R01 EB028773"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2021,4]]},"abstract":"\n Purpose<\/jats:title>\n \n Intraoperative T\n 2<\/jats:sub>\n \u2010weighted (T2\u2010w) imaging unreliably captures image contrast specific to thermal ablation after transcranial MR\u2010guided focused ultrasound surgery, impeding dynamic imaging feedback. Using a porcine thalamotomy model, we test the unproven hypothesis that intraoperative DWI can improve dynamic feedback by detecting lesioning within 30 minutes of transcranial MR\u2010guided focused ultrasound surgery.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Twenty\u2010five thermal lesions were formed in six porcine models using a clinical transcranial MR\u2010guided focused ultrasound surgery system. A novel diffusion\u2010weighted pulse sequence monitored the formation of T2\u2010w and diffusion\u2010weighted lesion contrast after ablation. Using postoperative T2\u2010w contrast to indicate lesioning, apparent intraoperative image contrasts and diffusion coefficients at each lesion site were computed as a function of time after ablation, observed peak temperature, and observed thermal dose. Lesion sizes segmented from imaging and thermometry were compared. Image reviewers estimated the time to emergence of lesion contrast. Intraoperative image contrasts were analyzed using receiver operator curves.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n On average, the apparent diffusion coefficient at lesioned sites decreased within 5 minutes after ablation relative to control sites. In\u2010plane lesion areas on intraoperative DWI varied from postoperative T2\u2010w MRI and MR thermometry by\n \n mm\n 2<\/jats:sup>\n and\n \n mm\n 2<\/jats:sup>\n , respectively. The 0.25, 0.5, and 0.75 quantiles of the earliest times of observed T2\u2010w and diffusion\u2010weighted lesion contrast were 10.7, 21.0, and 27.8 minutes and 3.7, 8.6, and 11.8 minutes, respectively. The T2\u2010w and diffusion\u2010weighted contrasts and apparent diffusion coefficient values produced areas under the receiver operator curve of 0.66, 0.80, and 0.74, respectively.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Intraoperative DWI can detect MR\u2010guided focused ultrasound surgery lesion formation in the brain within several minutes after treatment.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mrm.28537","type":"journal-article","created":{"date-parts":[[2020,11,11]],"date-time":"2020-11-11T05:40:33Z","timestamp":1605073233000},"page":"2145-2159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["A preclinical study of diffusion\u2010weighted MRI contrast as an early indicator of thermal ablation"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4778-8168","authenticated-orcid":false,"given":"Steven P.","family":"Allen","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Prada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Fondazione IRCCS Istituto Neurologico C. Besta Milan Italy"},{"name":"Department of Neurosurgery University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Gatesman","sequence":"additional","affiliation":[{"name":"Center for Comparative Medicine University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Sporkin","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yekaterina","family":"Gilbo","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydney","family":"DeCleene","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim Butts","family":"Pauly","sequence":"additional","affiliation":[{"name":"Department of Radiology Stanford University Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig H.","family":"Meyer","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Virginia Charlottesville Virginia USA"},{"name":"Department of Radiology University of Virginia Charlottesville Virginia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0281-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1300962"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.14.13632"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70048-6"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1600159"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.27587"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26997"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy278"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.04.007"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2586(200101)13:1<23::AID-JMRI1004>3.0.CO;2-G"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.204.1.9205255"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3808"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13126"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10439-007-9300-3"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20060"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.598707"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.11.FOCUS17623"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199908)10:2<146::AID-JMRI6>3.0.CO;2-C"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880080126"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(00)00216-7"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-5629(00)00275-1"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21688"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2361040312"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21589"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21415"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21801"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nicl.2019.101754"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.3171\/2014.8.JNS132603"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14132112"},{"key":"e_1_2_7_31_1","unstructured":"MazerolleE Warwaruk\u2010RogersR SevickR et al.MR\u2010guided focused ultrasound for essential tremor: Initial MRI observations. In: Proceedings of the 6th International Symposium on Focused Ultrasound Reston Virginia 2018."},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4928155"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00062-018-0709-x"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.3171\/2013.5.JNS122327"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0361-9230(99)00012-X"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40349-016-0047-x"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.13863"},{"key":"e_1_2_7_38_1","unstructured":"AuerbachE UgurbilK.Improvement in diffusion MRI at 3T and beyond with the twice\u2010refocused adiabatic spin echo (TRASE) sequence. In: Proceedings of the 12th Annual Meeting of ISMRM Kyoto Japan 2004. p2464."},{"key":"e_1_2_7_39_1","unstructured":"SkareS BalchandaniP NewbouldR BammerR.Adiabatic refocusing pulses in 3T and 7T diffusion imaging. In: Proceedings of the 15th Annual Meeting of ISMRM Montr\u00e9al Canada 2007. p1493."},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910180105"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20288"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25172"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27541"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10308"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910150211"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24542"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.97598"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20706"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910340618"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(93)90225-3"},{"key":"e_1_2_7_51_1","first-page":"33","volume-title":"Abstract Book of 19th International Symposium for Therapeutic Ultrasound","author":"Hadley JR","year":"2019"},{"key":"e_1_2_7_52_1","first-page":"36","volume-title":"Abstract Book of 19th International Symposium for Therapeutic Ultrasound","author":"Odeen H","year":"2019"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27987"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/60\/14\/5527"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.28537","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.28537","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.28537","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T05:34:23Z","timestamp":1693632863000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.28537"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11,11]]},"references-count":53,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/mrm.28537"],"URL":"https:\/\/doi.org\/10.1002\/mrm.28537","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.31225\/osf.io\/2qtnw","asserted-by":"object"}]},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,11,11]]},"assertion":[{"value":"2019-12-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-11-11","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}