{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T15:42:07Z","timestamp":1791906127437,"version":"4.3.4"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T00:00:00Z","timestamp":1611187200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["K23HL136904"],"award-info":[{"award-number":["K23HL136904"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Sickle cell anemia is a blood disorder that alters the morphology and the oxygen affinity of the red blood cells. Cerebral oxygen extraction fraction measurements using quantitative BOLD contrast have been used for assessing inadequate oxygen delivery and the subsequent risk of ischemic stroke in sickle cell anemia. The BOLD signal in MRI studies relies on <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28668-math-0001.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28668:mrm28668-math-0001\"\/>, the bulk volume susceptibility difference between fully oxygenated and fully deoxygenated blood. Several studies have measured <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28668-math-0002.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28668:mrm28668-math-0002\"\/> for normal hemoglobin A (HbA). However, it is not known whether the value is different for sickle hemoglobin. In this study, <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28668-math-0003.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28668:mrm28668-math-0003\"\/> was measured for both HbA and sickle hemoglobin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Six sickle cell anemia patients and 6 controls were recruited. Various blood oxygenation levels were achieved through in vivo manipulations to keep the blood close to its natural state. To account for the differences in oxygen affinity, Hill\u2019s equations were used to translate partial pressure of oxygen to oxygen saturation for HbA, sickle hemoglobin, and fetal hemoglobin (HbF) separately. The pH and PCO<jats:sub>2<\/jats:sub> corrections were performed. Temperature and magnetic field drift were controlled for. A multivariate generalized linear mixed model with random participant effect was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Assuming that <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28668-math-0004.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28668:mrm28668-math-0004\"\/> is similar for HbA and HbF and that <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28668-math-0005.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28668:mrm28668-math-0005\"\/> is 5\/4 of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28668-math-0006.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28668:mrm28668-math-0006\"\/> for HbA, it was found that the <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28668-math-0007.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28668:mrm28668-math-0007\"\/> values for HbA and sickle hemoglobin were not statistically significantly different from each other.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The same <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28668-math-0008.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28668:mrm28668-math-0008\"\/> value can be used for both types of hemoglobin in quantitative BOLD analysis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28668","type":"journal-article","created":{"date-parts":[[2021,1,21]],"date-time":"2021-01-21T18:20:04Z","timestamp":1611253204000},"page":"3383-3393","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Bulk volume susceptibility difference between deoxyhemoglobin and oxyhemoglobin for HbA and HbS: A comparative study"],"prefix":"10.1002","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4457-0916","authenticated-orcid":false,"given":"Cihat","family":"Eldeniz","sequence":"first","affiliation":[{"name":"Mallinckrodt Institute of Radiology Washington University in St. Louis St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7701-7615","authenticated-orcid":false,"given":"Michael M.","family":"Binkley","sequence":"additional","affiliation":[{"name":"Department of Neurology Washington University in St. Louis St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Fields","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Washington University in St. Louis St. Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Guilliams","sequence":"additional","affiliation":[{"name":"Department of Neurology 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