{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T07:50:47Z","timestamp":1769068247693,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["H2018089"],"award-info":[{"award-number":["H2018089"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901696"],"award-info":[{"award-number":["81901696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971572"],"award-info":[{"award-number":["81971572"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82001763"],"award-info":[{"award-number":["82001763"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore if R<jats:sub>2<\/jats:sub>\u2019 mapping can assess renal hypoxia in rabbits with ischemia reperfusion injury (IRI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty rabbits were randomly divided into 4 groups according to the clipping time: the sham group and 45 min, 60 min, and 75 min for the mild, moderate, and severe groups (with <jats:italic>n<\/jats:italic> = 10 each group), respectively. Intravenous furosemide (FU) was administered 24 h after IRI. All rabbits were performed 5 times (IRI<jats:sub>pre<\/jats:sub>, IRI<jats:sub>24h<\/jats:sub>, FU<jats:sub>5min<\/jats:sub>, FU<jats:sub>12min<\/jats:sub>, and FU<jats:sub>24min<\/jats:sub>) with a 3.0 Tesla MR. The R<jats:sub>2<\/jats:sub>\u2019 values and the hypoxic scores were then recorded. The repeated measurement analysis of variance and Spearman correlation analysis was used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the baseline, the medullary R<jats:sub>2<\/jats:sub>\u2019 values increased significantly 24 h after the IRI (baseline 19.31 \u00b1 1.21 s<jats:sup>\u20101<\/jats:sup>, mild group 20.05 \u00b1 1.26 s<jats:sup>\u22121<\/jats:sup>, moderate group 25.38 \u00b1 1.38 s<jats:sup>\u22121<\/jats:sup>, and severe group 25.79 \u00b1 1.10 s<jats:sup>\u22121<\/jats:sup>; each <jats:italic>P<\/jats:italic> &lt; .001). FU led to a significant decrease in the medullary R<jats:sub>2<\/jats:sub>\u2019 value (sham group 11.17 \u00b1 4.33 s<jats:sup>\u22121<\/jats:sup>, mild group 7.80 \u00b1 0.74 s<jats:sup>\u22121<\/jats:sup>, moderate group 3.92 \u00b1 0.28 s<jats:sup>\u22121<\/jats:sup>, and severe group 3.82 \u00b1 0.23 s<jats:sup>\u22121<\/jats:sup>; each <jats:italic>P<\/jats:italic> &lt; .05). Quantitative hypoxic scores revealed significant differences among the 4 groups in the outer medulla (<jats:italic>P<\/jats:italic> &lt; .001 each). The medullary R<jats:sub>2<\/jats:sub>\u2019 differences (before and after intravenous FU) were significantly correlated with the hypoxic scores, respectively (<jats:italic>P<\/jats:italic> &lt; .001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>R<jats:sub>2<\/jats:sub>\u2019 mapping can evaluate the renal hypoxia in the procession of IRI in rabbits and might serve as a quantitative biomarker for IRI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28696","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T12:37:02Z","timestamp":1615898222000},"page":"974-983","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Can R<sub>2<\/sub>\u2019 mapping evaluate hypoxia in renal ischemia reperfusion injury quantitatively? An experimental study"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-9790","authenticated-orcid":false,"given":"Jinggang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology Third Affiliated Hospital of Soochow University Changzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Third Affiliated Hospital of Soochow University Changzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Third Affiliated Hospital of Soochow University Changzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology Third Affiliated Hospital of Soochow University Changzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Radiology Third Affiliated Hospital of Soochow University Changzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liang","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Radiology Third Affiliated Hospital of Soochow University Changzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongcheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Third Affiliated Hospital of Soochow University Changzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqiang","family":"Dou","sequence":"additional","affiliation":[{"name":"MR research China, GE Healthcare Beijing People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2140-2685","authenticated-orcid":false,"given":"Wei","family":"Xing","sequence":"additional","affiliation":[{"name":"Department of Radiology Third Affiliated Hospital of Soochow University Changzhou People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199901)41:1<51::AID-MRM9>3.0.CO;2-G"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c110041"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-011-0495-0"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MNH.0b013e32834d085a"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1984.171"},{"key":"e_1_2_7_7_1","first-page":"253","article-title":"Outer medullary circulatory defect in ischemic acute renal failure","volume":"116","author":"Yamamoto K","year":"1984","journal-title":"Am J Pathol"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8030207"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13130367"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2015.06.018"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/0886022X.2014.976130"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.33176\/AACB-18-00017"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12149-013-0727-3"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.173.1.10397097"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semnuclmed.2010.08.003"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.16188.1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26985"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26772"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11307-018-1184-0"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1159\/000488072"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.04.015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3765"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3720"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000485600"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.006530"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-2004-3"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.017086"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1245597"},{"key":"e_1_2_7_29_1","first-page":"20","article-title":"Effects of the of renal warm ischemia time on the recovery of filtration function in the experiment","volume":"6","author":"Guseinov RG","year":"2017","journal-title":"Urologiia"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.04.010"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.3109\/09553002.2012.715789"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00083.2007"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2008.03.001"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.1998.274.2.F413"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.zemedi.2016.02.004"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31829d0414"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.TA.0000075331.21241.80"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3181f0213f"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e31829d0414"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.13122860"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mric.2008.07.008"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.28696","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.28696","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.28696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T12:30:25Z","timestamp":1693398625000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.28696"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,16]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/mrm.28696"],"URL":"https:\/\/doi.org\/10.1002\/mrm.28696","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,16]]},"assertion":[{"value":"2020-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}