{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:52:12Z","timestamp":1790787132148,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To study sub\u2010regional, longitudinal changes occurring inside brains of 5XFAD mice, an Alzheimer\u2019s disease (AD) model, based on viscoelastic parameters derived using MR elastography and their spatial variation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Female 5XFAD and non\u2010transgenic B6SJLF1\/J mice as controls (<jats:italic>n<\/jats:italic> = 9 for both groups) were used for the study. Scans were performed inside a 9.4T preclinical MRI scanner using SampLe Interval Modulation\u2010magnetic resonance elastography (SLIM\u2010MRE). Experiments were performed at ages 2, 4, and 6 mo, and by using three actuation frequencies: 900, 1000, and 1100 Hz. Multifrequency dual elasto\u2010visco (MDEV) reconstruction was used to combine 3D multifrequency MRE data and calculate magnitude <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28709-math-0001.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28709:mrm28709-math-0001\"\/>, and phase angle <jats:italic>\u03c6<\/jats:italic>, of the complex shear modulus <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28709-math-0002.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28709:mrm28709-math-0002\"\/>. Mean values were measured for the overall brain and sub\u2010regions associated with the early onset of AD, to check for the effect of aging and mouse model. Spatial coefficient of variation (CV) of both parameters across different age\u2010groups were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p><jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28709-math-0003.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28709:mrm28709-math-0003\"\/> and <jats:italic>\u03c6<\/jats:italic> values reduced with age for overall brain in 5XFAD mice with significant difference in mean <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28709-math-0004.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28709:mrm28709-math-0004\"\/> between 5XFAD and control mice at 6 mo (<jats:italic>P<\/jats:italic> = .029). Analyzing values from the hippocampal region highlighted drop in mean <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28709-math-0005.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28709:mrm28709-math-0005\"\/> and <jats:italic>\u03c6<\/jats:italic> values. The CV of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28709-math-0006.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28709:mrm28709-math-0006\"\/> inside hippocampus enabled differentiation at 4 mo with it being significantly lower in 5XFAD mice (<jats:italic>P<\/jats:italic> = .0007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Multifrequency 3D MRE revealed longitudinal viscoelastic changes in 5XFAD mice and the CV of <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/mrm28709-math-0007.png\" xlink:title=\"urn:x-wiley:07403194:media:mrm28709:mrm28709-math-0007\"\/> in brain sub\u2010regions may qualify as biomarker for early diagnosis of AD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28709","type":"journal-article","created":{"date-parts":[[2021,2,20]],"date-time":"2021-02-20T22:14:08Z","timestamp":1613859248000},"page":"405-414","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Longitudinal study of sub\u2010regional cerebral viscoelastic properties of 5XFAD Alzheimer's disease mice using multifrequency MR elastography"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1619-3682","authenticated-orcid":false,"given":"Shreyan","family":"Majumdar","sequence":"first","affiliation":[{"name":"Richard and Loan Hill Department of Bioengineering University of Illinois Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Klatt","sequence":"additional","affiliation":[{"name":"Richard and Loan Hill Department of Bioengineering University of Illinois Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(00)00039-6"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200102)45:2<299::AID-MRM1039>3.0.CO;2-O"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/61\/24\/R401"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jalz.2017.02.001","article-title":"2017 Alzheimer\u2019s disease facts and figures","volume":"13","author":"Alzheimer\u2019s Association","year":"2018","journal-title":"Alzheimer\u2019s Dement"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-018-0107-y"},{"key":"e_1_2_6_7_1","volume-title":"Neurological Disorders: Public Health Challenges","author":"World Health Organization","year":"2006"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.22707"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2011.12.019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1202-06.2006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/aa8444"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24674"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0064078"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-2"},{"key":"e_1_2_6_15_1","unstructured":"MajumdarS KlattD.Comparison of MR Elastography data from the mouse brain using single\u2010frequency algebraic inversion and MDEV inversion. 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