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We also proposed a novel, single\u2010point Dixon (spDixon)\u2010based approach for fat suppression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The UTE\u2010Cones\u2010DESS sequence was implemented on a 3T MR system. It uses a short radiofrequency (RF) pulse followed by a pair of balanced spiral\u2010out and spiral\u2010in readout gradients separated by an unbalanced spoiling gradient in\u2010between. The readout gradients are applied immediately before or after the RF pulses to achieve a UTE image (S<jats:sub>+<\/jats:sub>) and a spin\/stimulated echo image (S<jats:sub>\u2212<\/jats:sub>). Weighted echo subtraction between S<jats:sub>+<\/jats:sub> and S<jats:sub>\u2212<\/jats:sub> was performed to achieve high contrast specific to short T<jats:sub>2<\/jats:sub> tissues, and spDixon was applied to suppress fat by using the intrinsic complex signal of S<jats:sub>+<\/jats:sub> and S<jats:sub>\u2212<\/jats:sub>. Six healthy volunteers and five patients with osteoarthritis were recruited for whole\u2010knee imaging. Additionally, two healthy volunteers were recruited for lower leg imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The UTE\u2010Cones\u2010DESS sequence allows fast volumetric imaging of musculoskeletal tissues with excellent image contrast for the osteochondral junction, tendons, menisci, and ligaments in the knee joint as well as cortical bone and aponeurosis in the lower leg within 5 min. spDixon yields efficient fat suppression in both S<jats:sub>+<\/jats:sub> and S<jats:sub>\u2212<\/jats:sub> images without requiring any additional acquisitions or preparation pulses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The rapid UTE\u2010Cones\u2010DESS sequence can be used for high contrast morphological imaging of short T<jats:sub>2<\/jats:sub> tissues, providing a new tool to assess their association with musculoskeletal 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