{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T13:26:02Z","timestamp":1789392362375,"version":"build-2803163510"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T00:00:00Z","timestamp":1616457600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R01 MH084021"],"award-info":[{"award-number":["R01 MH084021"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS107417"],"award-info":[{"award-number":["R01 NS107417"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01 NS109029"],"award-info":[{"award-number":["R01 NS109029"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To validate two neonatal cerebral venous oxygenation (Y<jats:sub>v<\/jats:sub>) MRI techniques, T<jats:sub>2<\/jats:sub> relaxation under phase contrast (TRUPC) and accelerated TRUPC (aTRUPC) MRI, with oxygenation measured with direct blood sampling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In vivo experiments were performed on seven healthy newborn piglets. For each piglet, a catheter was placed in the superior sagittal sinus to obtain venous blood samples for blood gas oximetry measurement as a gold standard. During the MRI experiment, three to five venous oxygenation levels were achieved in each piglet by varying inhaled O<jats:sub>2<\/jats:sub> content and breathing rate. Under each condition, Y<jats:sub>v<\/jats:sub> values of the superior sagittal sinus measured by TRUPC, aTRUPC, and blood gas oximetry were obtained. The Y<jats:sub>v<\/jats:sub> quantification in TRUPC and aTRUPC used a standard bovine blood calibration model. The aTRUPC scan was repeated twice to assess its reproducibility. Agreements among TRUPC Y<jats:sub>v<\/jats:sub>, aTRUPC Y<jats:sub>v<\/jats:sub>, and blood gas oximetry were evaluated by intraclass correlation coefficient (ICC) and paired Student\u2019s t\u2010test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean hematocrit was 23.6 \u00b1 6.5% among the piglets. Across all measurements, Y<jats:sub>v<\/jats:sub> values were 51.9 \u00b1 21.3%, 54.1 \u00b1 18.8%, and 53.7 \u00b1 19.2% for blood gas oximetry, TRUPC and aTRUPC, respectively, showing no significant difference between any two methods (<jats:italic>P<\/jats:italic> &gt; .3). There were good correlations between TRUPC and blood gas Y<jats:sub>v<\/jats:sub> (ICC = 0.801; <jats:italic>P<\/jats:italic> &lt; .0001), between aTRUPC and blood gas Y<jats:sub>v<\/jats:sub> (ICC = 0.809; <jats:italic>P<\/jats:italic> &lt; .0001), and between aTRUPC and TRUPC Y<jats:sub>v<\/jats:sub> (ICC = 0.887; <jats:italic>P<\/jats:italic> &lt; .0001). The coefficient of variation of aTRUPC Y<jats:sub>v<\/jats:sub> was 8.1 \u00b1 9.9%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The values of Y<jats:sub>v<\/jats:sub> measured by TRUPC and aTRUPC were in good agreement with blood gas oximetry. These findings suggest that TRUPC and aTRUPC can provide accurate quantifications of Y<jats:sub>v<\/jats:sub> in major cerebral veins.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28786","type":"journal-article","created":{"date-parts":[[2021,3,23]],"date-time":"2021-03-23T10:33:55Z","timestamp":1616495635000},"page":"1445-1453","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Quantitative validation of MRI mapping of cerebral venous oxygenation with direct blood sampling: A graded\u2010O<sub>2<\/sub> study in piglets"],"prefix":"10.1002","volume":"86","author":[{"given":"Dengrong","family":"Jiang","sequence":"first","affiliation":[{"name":"The Russell H. Morgan Department of Radiology &amp; Radiological Science Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond C.","family":"Koehler","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuyun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ewa","family":"Kulikowicz","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer K.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3871-1564","authenticated-orcid":false,"given":"Hanzhang","family":"Lu","sequence":"additional","affiliation":[{"name":"The Russell H. 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