{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T19:43:40Z","timestamp":1786391020353,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,7,15]],"date-time":"2021-07-15T00:00:00Z","timestamp":1626307200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["1U01HD087202\u201001"],"award-info":[{"award-number":["1U01HD087202\u201001"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To provide a new approach to jointly assess microstructural and molecular properties of the human placenta in vivo fast and efficiently and to present initial evidence in cohorts of healthy pregnancies and those affected by pre\u2010eclampsia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Slice and diffusion preparation shuffling, built on the previously proposed ZEBRA method, is presented as a robust and fast way to obtain  and apparent diffusivity coefficient (ADC) values. Joint modeling and evaluation is performed on a cohort of healthy and pre\u2010eclamptic participants at 3T.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The datasets show the ability to obtain robust and fast \u2010ADC measurements. Significant decay over gestation in  (\u221211 ms\/week, ) and a trend toward significance in ADC (\u22120.23 mm\/\/week,\n                      <jats:italic>P<\/jats:italic>\n                      = .08) values can be observed in a control cohort. Values for the pre\u2010eclamptic pregnancies show a negative trend for both ADC and .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The presented sequence allows the simultaneous acquisition of 2 of the most promising quantitative parameters to study placental insufficiency\u2014identified individually as relevant in previous studies\u2014in under 2 minutes. This allows dynamic assessment of physiological processes, reduced inconsistency in spatial comparisons due to reduced motion artefacts and opens novel avenues for analysis. Initial results in pre\u2010eclamptic placentas, with depicted changes in both ADC and , illustrate its potential to identify cases of placental insufficiency. Future work will focus on expanding the field\u2010of\u2010view using multi\u2010band acceleration techniques and the expansion to larger and more diverse patient groups.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.28809","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:21:59Z","timestamp":1626394919000},"page":"2684-2691","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["An efficient and combined placental T1\u2010ADC acquisition in pregnancies with and without pre\u2010eclampsia"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-3500","authenticated-orcid":false,"given":"Jana","family":"Hutter","sequence":"first","affiliation":[{"name":"Center for Medical Engineering King\u2019s College London London UK"},{"name":"Center for the Developing Brain, School of Biomedical Engineering and Imaging King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Ho","sequence":"additional","affiliation":[{"name":"Academic Women\u2019s Health Department King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence H.","family":"Jackson","sequence":"additional","affiliation":[{"name":"Center for Medical Engineering King\u2019s College London London UK"},{"name":"Center for the Developing Brain, School of Biomedical Engineering and Imaging King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paddy J.","family":"Slator","sequence":"additional","affiliation":[{"name":"Centre for Medical Image Computing, Department of Computer Science University College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucy C.","family":"Chappell","sequence":"additional","affiliation":[{"name":"Academic Women\u2019s Health Department King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph V.","family":"Hajnal","sequence":"additional","affiliation":[{"name":"Center for Medical Engineering King\u2019s College London London UK"},{"name":"Center for the Developing Brain, School of Biomedical Engineering and Imaging King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary A.","family":"Rutherford","sequence":"additional","affiliation":[{"name":"Center for Medical Engineering King\u2019s College London London UK"},{"name":"Center for the Developing Brain, School of Biomedical Engineering and Imaging King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,15]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.009"},{"key":"e_1_2_6_3_1","article-title":"T2s Placental magnetic resonance imaging in preterm preeclampsia: an observational cohort study","volume":"1523","author":"Ho AEP","year":"2020","journal-title":"Hypertension"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27733"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27406"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/uog.20855"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303052"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910400318"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2017162385"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24581"},{"key":"e_1_2_6_11_1","unstructured":"StoutJN RouhaniS LiaoC et al.Placental MRI: using a novel ex vivo placental perfusion chamber to validate in vivo magnetic resonance fingerprinting (MRF) relaxometry. 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