{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:15:13Z","timestamp":1768976113496,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T00:00:00Z","timestamp":1627862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007851","name":"National Physical Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007851","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To characterize the diffusion time\u2010dependence in muscle in healthy adult volunteers, boys with Duchenne\u2019s muscular dystrophy (DMD), and age\u2010matched controls in a clinically feasible acquisition time for pediatric applications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Diffusion data were acquired using a pulsed gradient stimulated echo diffusion preparation at 5 different diffusion times (70, 130, 190, 250, and 330 ms), at 4 different b\u2010values (0, 200, 400, 600, and 800 s\/mm<jats:sup>2<\/jats:sup>) and 6 directions (orthogonal x, y, and z and diagonal xy, xz, and yz) and processed to obtain standard diffusion indices (mean diffusivity [MD] and fractional anisotropy [FA]) at each diffusion time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Time\u2010dependent diffusion was seen in muscle in healthy adult volunteers, boys with DMD, and age\u2010matched controls. Boys with DMD showed reduced MD and increased FA values in comparison to age matched controls across a range of diffusion times. A diffusion time of \u0394 = 190 ms had the largest effect size.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results could be used to optimize diffusion imaging in this disease further and imply that these diffusion indices may become an important biomarker in monitoring progression in DMD in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.28945","type":"journal-article","created":{"date-parts":[[2021,8,2]],"date-time":"2021-08-02T07:31:35Z","timestamp":1627889495000},"page":"3192-3200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Clinically feasible diffusion MRI in muscle: Time dependence and initial findings in Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4886-6191","authenticated-orcid":false,"given":"Amy R.","family":"McDowell","sequence":"first","affiliation":[{"name":"Developmental Imaging and Biophysics University College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thorsten","family":"Feiweier","sequence":"additional","affiliation":[{"name":"Siemens Healthcare GmbH Erlangen Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Muntoni","sequence":"additional","affiliation":[{"name":"UCL GOS Institute of Child Health University College London London United Kingdom"},{"name":"NIHR Great Ormond Street Hospital Biomedical Research Centre, Great Ormond Street Institute of Child Health University College London London United Kingdom"},{"name":"Great Ormond Street Hospital Trust London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matt G.","family":"Hall","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Biophysics University College London London United Kingdom"},{"name":"National Physical Laboratory London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris A.","family":"Clark","sequence":"additional","affiliation":[{"name":"Developmental Imaging and Biophysics University College London London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,8,2]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-014-3187-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.15.15028"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3427"},{"key":"e_1_2_8_5_1","first-page":"305","volume-title":"3.5 \u2010 Contractile Mechanisms in Skeletal Muscle. 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