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Two STEAM\u2010MRS sequences (multi\u2010TE and multi\u2010TE\u2010TR) were acquired at both 1.5T and 3T (same day), including test\u2013retest acquisition. Each acquisition enabled estimation of <jats:italic>R<\/jats:italic>1, <jats:italic>R<\/jats:italic>2, and <jats:italic>FWHM<\/jats:italic> (each separately for water and fat); and proton density fat fraction. The test\u2013retest repeatability and reproducibility across acquisition modes (multi\u2010TE vs. multi\u2010TE\u2010TR) of the estimates were evaluated using intraclass correlation coefficients, linear regression, and Bland\u2010Altman analyses. Multi\u2010parametric relationships between parameters at each field strength, across field strengths, and with liver iron concentration were also evaluated using linear and nonlinear regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010six (n = 56) subjects (10 to 73 years, 37 males\/19 females) were successfully recruited. Both STEAM\u2010MRS sequences demonstrated good\u2010to\u2010excellent precision (intraclass correlation coefficient \u2265 0.81) for the quantification of <jats:italic>R<\/jats:italic>1<jats:italic><jats:sub>water<\/jats:sub><\/jats:italic>, <jats:italic>R<\/jats:italic>2<jats:italic><jats:sub>water<\/jats:sub><\/jats:italic>, <jats:italic>FWHM<jats:sub>water<\/jats:sub><\/jats:italic>, and proton density fat fraction at both 1.5T and 3T. Additionally, several moderate (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.50 to 0.69) to high (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> \u2265 0.70) correlations were observed between biomarkers, across field strengths, and with liver iron concentration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Over a broad range of liver iron concentration, STEAM\u2010MRS enables rapid and precise measurement of multiple biomarkers of chronic liver disease. By evaluating the multi\u2010parametric relationships between biomarkers, this work may advance the comprehensive MRS\u2010based assessment of chronic liver disease and may help establish biomarkers of chronic liver disease.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29021","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T16:34:34Z","timestamp":1632414874000},"page":"597-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Spectroscopy\u2010based multi\u2010parametric quantification in subjects with liver iron overload at 1.5T and 3T"],"prefix":"10.1002","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9326-7203","authenticated-orcid":false,"given":"Gregory","family":"Simchick","sequence":"first","affiliation":[{"name":"Department of Radiology University of Wisconsin\u2010Madison  Madison Wisconsin 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