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The four\u2010dimensional\u2010navigator is inserted into the relaxation\u2010recovery deadtime of the sequence in every pulse TR (\u223c2\u00a0s) to avoid extra scan time, and to provide continuous tracking of the 3D head motion and <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub>\u2010inhomogeneity changes. By using an optimized spatiotemporal encoding combined with a partial\u2010Fourier scheme, the navigator acquires a large central <jats:italic>k\u2010t<\/jats:italic> data block for accurate motion estimation using only four small\u2010flip\u2010angle excitations and readouts, resulting in negligible signal\u2010recovery reduction to the 3D\u2010echo\u2010planar time\u2010resolved imaging acquisition. By incorporating the estimated motion and <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub>\u2010inhomogeneity changes into the reconstruction, multi\u2010contrast images can be recovered with reduced motion artifacts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Simulation shows the cost to the SNR efficiency from the added navigator acquisitions is &lt;1%. Both simulation and in vivo retrospective experiments were conducted, that demonstrate the four\u2010dimensional navigator provided accurate estimation of the 3D motion and <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub>\u2010inhomogeneity changes, allowing effective reduction of image artifacts in quantitative maps. Finally, in vivo prospective undersampling acquisition was performed with and without head motion, in which the motion corrupted data after correction show close image quality and consistent quantifications to the motion\u2010free scan, providing reliable quantitative measurements even with head motion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed four\u2010dimensional navigator acquisition provides reliable tracking of the head motion and <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub> change with negligible SNR cost, equips the 3D\u2010echo\u2010planar time\u2010resolved imaging technique for motion\u2010robust and efficient quantitative imaging.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29277","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T09:53:24Z","timestamp":1651139604000},"page":"1112-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Motion\u2010corrected 3D\u2010EPTI with efficient 4D navigator acquisition for fast and robust whole\u2010brain quantitative imaging"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9334-0968","authenticated-orcid":false,"given":"Zijing","family":"Dong","sequence":"first","affiliation":[{"name":"Athinoula A. 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