{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T16:41:39Z","timestamp":1791650499749,"version":"4.3.4"},"reference-count":69,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100013429","name":"Delaware IDeA Network of Biomedical Research Excellence","doi-asserted-by":"publisher","award":["P20\u2010GM103446"],"award-info":[{"award-number":["P20\u2010GM103446"]}],"id":[{"id":"10.13039\/100013429","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002369","name":"University of Delaware Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002369","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31\u2010HD103361"],"award-info":[{"award-number":["F31\u2010HD103361"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010AG058853"],"award-info":[{"award-number":["R01\u2010AG058853"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01\u2010EB027577"],"award-info":[{"award-number":["R01\u2010EB027577"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01\u2010NS112120"],"award-info":[{"award-number":["U01\u2010NS112120"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>MR elastography (MRE) is a technique to characterize brain mechanical properties in vivo. Due to the need to capture tissue deformation in multiple directions over time, MRE is an inherently long acquisition, which limits achievable resolution and use in challenging populations. The purpose of this work is to develop a method for accelerating MRE acquisition by using low\u2010rank image reconstruction to exploit inherent spatiotemporal correlations in MRE data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Theory and Methods<\/jats:title><jats:p>The proposed MRE sampling and reconstruction method, OSCILLATE (Observing Spatiotemporal Correlations for Imaging with Low\u2010rank Leveraged Acceleration in Turbo Elastography), involves alternating which k\u2010space points are sampled between each repetition by a reduction factor, <jats:italic>R<\/jats:italic><jats:sub>OSC.<\/jats:sub> Using a predetermined temporal basis from a low\u2010resolution navigator in a joint low\u2010rank image reconstruction, all images can be accurately reconstructed from a reduced amount of k\u2010space data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Decomposition of MRE displacement data demonstrated that, on average, 96.1% of all energy from an MRE dataset is captured at rank <jats:italic>L<\/jats:italic>\u00a0=\u00a012 (reduced from a full rank of 24). Retrospectively undersampling data with <jats:italic>R<\/jats:italic><jats:sub>OSC<\/jats:sub>\u00a0=\u00a02 and reconstructing at low\u2010rank (<jats:italic>L<\/jats:italic>\u00a0=\u00a012) yields highly accurate stiffness maps with voxel\u2010wise error of 5.8%\u2009\u00b1\u20090.7%. Prospectively undersampled data at <jats:italic>R<\/jats:italic><jats:sub>OSC<\/jats:sub>\u00a0=\u00a02 were successfully reconstructed without loss of material property map fidelity, with average global stiffness error of 1.0%\u2009\u00b1\u20090.7% compared to fully sampled data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>OSCILLATE produces whole\u2010brain MRE data at 2\u2009mm isotropic resolution in 1\u00a0min 48\u2009s.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29308","type":"journal-article","created":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T19:48:40Z","timestamp":1654112920000},"page":"1659-1672","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["<scp>OSCILLATE<\/scp>: A low\u2010rank approach for accelerated magnetic resonance elastography"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6594-8757","authenticated-orcid":false,"given":"Grace","family":"McIlvain","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3099-2392","authenticated-orcid":false,"given":"Alexander M.","family":"Cerjanic","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"},{"name":"University of Illinois College of Medicine  Urbana Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9334-8684","authenticated-orcid":false,"given":"Anthony G.","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars\u2010Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8430-800X","authenticated-orcid":false,"given":"Matthew D. J.","family":"McGarry","sequence":"additional","affiliation":[{"name":"Thayer School of Engineering Dartmouth College  Hanover New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7760-131X","authenticated-orcid":false,"given":"Curtis L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Biomedical Engineering University of Delaware  Newark Delaware USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(00)00039-6"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2018.06.001"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.08.036"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2009.02.040"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.01.010"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.10.008"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.01.007"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.03.061"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dcn.2017.08.010"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa388"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361-6560\/ac5fde"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2017.11.045"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2021.102212"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1115\/1.4046199"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmbbm.2016.03.005"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/57\/12\/4023"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/57\/12\/4041"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2010.06.016"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27083"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25065"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28855"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28445"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.12.032"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/58\/24\/8663"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24806"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25280"},{"key":"e_1_2_8_28_1","first-page":"1","article-title":"Analysis and improvement of motion encoding in magnetic resonance elastography","volume":"31","author":"Guenthner C","year":"2018","journal-title":"NMR Biomed"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2958"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4049"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25240"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2013.2293974"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25421"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26019"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28526"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26382"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.02.062"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2021.118235"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2020.3017450"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2013.2266096"},{"key":"e_1_2_8_41_1","doi-asserted-by":"crossref","unstructured":"ZhaoB HaldarJP BrinegarC LiangZP.Low rank matrix recovery for real\u2010time cardiac MRI. In Proceedings of 2010 7th IEEE Int Symp Biomed Imaging from Nano to Macro ISBI 2010;2010 pp.996\u2013999.","DOI":"10.1109\/ISBI.2010.5490156"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2014.2321190"},{"key":"e_1_2_8_43_1","unstructured":"McIlvainG CerjanicAM ChristodoulouAG McGarryMD JohnsonCL.OSCILLATE: a low\u2010rank approach for accelerated magnetic resonance elastography. In 28th Annual Meeting of the International Society for Magnetic Resonance in Medicine;2020."},{"key":"e_1_2_8_44_1","doi-asserted-by":"crossref","unstructured":"LiangZ. Spatiotemporal imaging with partially separable functions. In 2007 4th IEEE Int Symp Biomed Imaging from Nano to Macro; 2007 vol. 2 pp. 988\u2010991.","DOI":"10.1109\/ISBI.2007.357020"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29050"},{"key":"e_1_2_8_46_1","unstructured":"JohnsonCL HoltropJL AndersonAT SuttonBP.Brain MR elastography with multiband excitation and nonlinear motion\u2010induced phase error correction. In 24th Annual Meeting of the Interational Society for Magnetic Resonance in Medicine Singapore;2016 p.1951."},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199908)42:2<412::AID-MRM25>3.0.CO;2-U"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1241"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24473"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24875"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20288"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2002.808360"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2008.923956"},{"key":"e_1_2_8_54_1","first-page":"14","article-title":"PowerGrid: a open source library for accelerated iterative magnetic resonance image reconstruction","author":"Cerjanic A","year":"2016","journal-title":"Proc Intl Soc Mag Reson Med"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4754649"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1111"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1109\/42.906424"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1361-8415(01)00036-6"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10493"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22318"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1189"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.23314"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0081668"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/56\/19\/014"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/57\/8\/2329"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200102)45:2<299::AID-MRM1039>3.0.CO;2-O"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27019"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2020.101710"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4616"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.29308","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mrm.29308","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.29308","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T13:44:21Z","timestamp":1692625461000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.29308"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":69,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1002\/mrm.29308"],"URL":"https:\/\/doi.org\/10.1002\/mrm.29308","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"2021-12-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}