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Individual acquisitions of DWI signal intensities were reconstructed to calculate inter\u2010acquisition distributions and their statistics, which were compared for healthy versus cancer tissue. A method was proposed to detect and filter the acquisitions affected by motion\u2010induced signal loss. First, signals that reflect restricted diffusion were separated from the acquisitions that suffer from signal loss, likely due to microscopic motion, by imposing a cutoff value. Furthermore, corrected apparent diffusion coefficient maps were calculated by employing a weighted sum of the multiple acquisitions, instead of conventional averaging. These weights were calculated by applying a soft\u2010max function to the set of acquisitions per\u2010voxel, making the analysis immune to acquisitions with significant signal loss, even if the number of such acquisitions is high.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Inter\u2010acquisition variation is much larger than the Rician noise variance, local spatial variations, and the estimates of diffusion anisotropy based on the current data, as well as the published values of anisotropy. The proposed method increases the contrast for cancers and yields a sensitivity of  with a false positive rate of .<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Motion\u2010induced signal loss makes conventional signal\u2010averaging suboptimal and can obscure signals from areas with restricted diffusion. Filtering or weighting individual acquisitions prior to image analysis can overcome this problem.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29385","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T11:20:13Z","timestamp":1658402413000},"page":"2298-2310","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Directional and inter\u2010acquisition variability in diffusion\u2010weighted imaging and editing for restricted diffusion"],"prefix":"10.1002","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9395-7519","authenticated-orcid":false,"given":"Batuhan","family":"Gundogdu","sequence":"first","affiliation":[{"name":"Department of Radiology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay M.","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Chicago  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