{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:05:12Z","timestamp":1789178712948,"version":"build-2803163510"},"reference-count":62,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,9,11]],"date-time":"2022-09-11T00:00:00Z","timestamp":1662854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["5R01DK121847\u201002"],"award-info":[{"award-number":["5R01DK121847\u201002"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P41EB024495"],"award-info":[{"award-number":["P41EB024495"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>To assess the potential of DCE MR CEST urography for assessing renal function in mice with unilateral ureter obstruction (UUO) by simultaneous pH and renal uptake\/clearance measurements following injection of iopamidol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The right ureter of nine mice was obstructed via suture ligation. The animals were imaged at day 1, 2, and 3 post\u2010obstruction on an 11.7T MRI scanner. Ninety\u2010six sets of saturated CEST images at 4.3 and 5.5\u00a0ppm were collected. Renal pH values were obtained by calculating the signal ratio for these two frequencies and using a pH calibration curve. Renal time activity curves were measured as a percentage change in the post\u2010injection CEST signal at 4.3\u00a0ppm relative to the average pre\u2010injection signal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>For the healthy mice, the time activity curves of both kidneys were nearly identical and displayed rapid excretion of contrast. For the UUO mice, the dynamic CEST curves for the obstructed kidneys displayed prolonged time to peak (TTP) values and delayed contrast excretion compared with the contralateral (CL) kidneys. Renal pH maps of the healthy animals showed similar acidic values for both kidneys (pH\u00a06.65\u2009\u00b1\u20090.04 vs 6.67\u2009\u00b1\u20090.02), whereas in the obstructed kidneys there was a significant increase in pH values compared with the CL kidneys (pH\u00a06.67\u2009\u00b1\u20090.08 vs 6.79\u2009\u00b1\u20090.11 in CL and UUO kidneys, respectively).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings indicate that DCE\u2010MR\u2010CEST urography can detect changes in renal uptake\/excretion and pH homeostasis and distinguish between obstructed and unobstructed kidney as early as 1\u2009day after UUO.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.29436","type":"journal-article","created":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T01:59:26Z","timestamp":1662947966000},"page":"343-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Noninvasive assessment of renal dynamics and\n                    <scp>pH<\/scp>\n                    in a unilateral ureter obstruction model using\n                    <scp>DCE MR\u2010CEST<\/scp>\n                    urography"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2730-4250","authenticated-orcid":false,"given":"Julia","family":"Stabinska","sequence":"first","affiliation":[{"name":"F.M. 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Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9067-3684","authenticated-orcid":false,"given":"Farzad","family":"Sedaghat","sequence":"additional","affiliation":[{"name":"Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Kates","sequence":"additional","affiliation":[{"name":"James Buchanan Brady Urological Institute and Department of Urology Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8917-7640","authenticated-orcid":false,"given":"Michael T.","family":"McMahon","sequence":"additional","affiliation":[{"name":"F.M. 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