{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:51:00Z","timestamp":1789419060418,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["Z01\u2010HL006041"],"award-info":[{"award-number":["Z01\u2010HL006041"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>We describe a clinical grade, \u201cactive\u201d, monopole antenna\u2010based metallic guidewire that has a continuous shaft\u2010to\u2010tip image profile, a pre\u2010shaped tip\u2010curve, standard 0.89\u2009mm (0.035\u2033) outer diameter, and a detachable connector for catheter exchange during cardiovascular catheterization at 0.55T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Electromagnetic simulations were performed to characterize the magnetic field around the antenna whip for continuous tip visibility. The active guidewire was manufactured using medical grade materials in an ISO Class 7 cleanroom. RF\u2010induced heating of the active guidewire prototype was tested in one gel phantom per ASTM 2182\u201019a, alone and in tandem with clinical metal\u2010braided catheters. Real\u2010time MRI visibility was tested in one gel phantom and in\u2010vivo in two swine. Mechanical performance was compared with commercial equivalents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The active guidewire provided continuous \u201cprofile\u201d shaft and tip visibility in\u2010vitro and in\u2010vivo, analogous to guidewire shaft\u2010and\u2010tip profiles under X\u2010ray. The MRI signal signature matched simulation results. Maximum unscaled RF\u2010induced temperature rise was 5.2\u00b0C and 6.5\u00b0C (3.47\u2009W\/kg local background specific absorption rate), alone and in tandem with a steel\u2010braided catheter, respectively. Mechanical characteristics matched commercial comparator guidewires.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The active guidewire was clearly visible via real\u2010time MRI at 0.55T and exhibits a favorable geometric sensitivity profile depicting the guidewire continuously from shaft\u2010to\u2010tip including a unique curved\u2010tip signature. RF\u2010induced heating is clinically acceptable. This design allows safe device navigation through luminal structures and heart chambers. The detachable connector allows delivery and exchange of cardiovascular catheters while maintaining guidewire position. This enhanced guidewire design affords the expected performance of X\u2010ray guidewires during human MRI catheterization.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29466","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T18:21:50Z","timestamp":1664994110000},"page":"845-858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["An interventional MRI guidewire combining profile and tip conspicuity for catheterization at 0.55T"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1145-939X","authenticated-orcid":false,"given":"Dursun Korel","family":"Yildirim","sequence":"first","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health  Bethesda Maryland 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Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby","family":"Rogers","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William H.","family":"Schenke","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health  Bethesda Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajiv","family":"Ramasawmy","sequence":"additional","affiliation":[{"name":"Cardiovascular Branch, Division of Intramural Research National Heart Lung and Blood Institute, National Institutes of Health  Bethesda Maryland 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