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Fetal infection may occur in the absence of maternal symptoms, delaying diagnosis and increasing morbidity and mortality. A noninvasive antenatal assessment of early signs of placental inflammation is therefore urgently required.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen women with preterm premature rupture of membranes &lt;\u200934\u2009weeks gestation and 60 women with uncomplicated pregnancies were prospectively recruited. A modified diffusion\u2010weighted spin\u2010echo single shot EPI sequence with a diffusion preparation acquiring 264 unique parameter combinations in &lt;\u20099\u00a0min was obtained on a clinical 3 Tesla MRI scanner. The data was fitted to a 2\u2010compartment \u2010intravoxel incoherent motion model comprising fast and slowly circulating fluid pools to obtain quantitative information on perfusion, density, and tissue composition. <jats:italic>Z<\/jats:italic> values were calculated, and correlation with time from between the rupture of membranes and the scan, gestational age at delivery, and time between scan and delivery assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Placental  was significantly reduced in preterm premature rupture of membranes, and the 2\u2010compartmental model demonstrated that this decline is mainly linked to the perfusion component observed in the placental parenchyma. Multi\u2010modal MRI measurement of placental function is linked to gestational age at delivery and time from membrane rupture.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>More complex models and data acquisition can potentially improve fitting of the underlying etiology of preterm birth compared with individual single\u2010contrast models and contribute to additional insights in the future. This will need validation in larger cohorts. A multi\u2010modal MRI acquisition between rupture of the membranes and delivery can be used to measure placental function and is linked to gestational age at delivery.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29483","type":"journal-article","created":{"date-parts":[[2022,10,18]],"date-time":"2022-10-18T12:37:46Z","timestamp":1666096666000},"page":"1151-1159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multi\u2010modal <scp>MRI<\/scp> reveals changes in placental function following preterm premature rupture of membranes"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-3500","authenticated-orcid":false,"given":"Jana","family":"Hutter","sequence":"first","affiliation":[{"name":"Centre for the Developing Brain King's College London   London United Kingdom"},{"name":"Centre for Medical Engineering King's College London  London United 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