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The new method, called Sandwich,\u00a0is evaluated as a 3D sequence, measuring whole\u2010brain and gated whole\u2010heart B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> maps in a single breath\u2010hold. We evaluate the sensitivity to B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> and T<jats:sub>1<\/jats:sub> using numerical Bloch, extended phase graph, and Monte Carlo simulations. Phantom and in vivo images were acquired in both the brain and heart using an 8\u2010channel transmit 7 Tesla MRI system to support the simulations. A segmented satTFL with a short readout train was used as a reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The method significantly reduces acquisition times of 3D measurements from 360\u2009s to 20\u2009s, in the brain, while simultaneously reducing bias in the measured B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> due to T<jats:sub>1<\/jats:sub> and magnetization history. The mean coefficient of variation was reduced by 81% for T<jats:sub>1<\/jats:sub>s of 0.5\u20133\u00a0s compared to conventional satTFL. In vivo, the reproducibility coefficient for flip angles in the range 0\u2013130\u00b0 was 4.5\u00b0 for satTFL and 4.7\u00b0 for our scheme, significantly smaller than for a short TR satTFL sequence, which was 12\u00b0. The 3D sequence measured B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> maps of the whole thorax in 26 heartbeats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our adaptations enable faster B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> mapping, with minimal T<jats:sub>1<\/jats:sub> sensitivity and lower sensitivity to magnetization history, enabling single breath\u2010hold whole\u2010heart absolute B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup> mapping.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29497","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T06:21:40Z","timestamp":1667802100000},"page":"964-976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Rapid 3D absolute B<sub>1<\/sub><sup>+<\/sup> mapping using a sandwiched train presaturated TurboFLASH sequence at 7\u2009T for the brain and heart"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6482-7515","authenticated-orcid":false,"given":"James L.","family":"Kent","sequence":"first","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford   Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iulius","family":"Dragonu","sequence":"additional","affiliation":[{"name":"Siemens Healthcare Limited  Frimley Surrey UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2567-3642","authenticated-orcid":false,"given":"Ladislav","family":"Valkovi\u010d","sequence":"additional","affiliation":[{"name":"Oxford Centre for Clinical Magnetic Resonance Research (OCMR) University of Oxford  Oxford UK"},{"name":"Department of Imaging Methods Institute of Measurement Science, Slovak Academy of Sciences  Bratislava Slovakia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9289-5619","authenticated-orcid":false,"given":"Aaron T.","family":"Hess","sequence":"additional","affiliation":[{"name":"Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford   Oxford UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(76)90233-X"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmr.10007"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20011"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3313"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22978"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21739"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22527"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26925"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1088\/0031-9155\/55\/20\/008"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21120"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21592"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22357"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26395"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24158"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(85)90033-2"},{"key":"e_1_2_11_17_1","unstructured":"B\u00f6rnertP NehrkeK JinnanW.Magnetization prepared DREAM for fast flow\u2010robust B1+ mapping. 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