{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:51:35Z","timestamp":1786978295483,"version":"build-2736575974"},"reference-count":31,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT\u20101530399"],"award-info":[{"award-number":["PJT\u20101530399"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      To demonstrate the feasibility of a rapid 3D stack\u2010of\u2010spirals (3D\u2010SoS) imaging acquisition for hyperpolarized\n                      <jats:sup>129<\/jats:sup>\n                      Xe ventilation mapping in healthy pediatric participants and pediatric cystic fibrosis (CF) participants, in comparison to conventional Cartesian multislice (2D) gradient\u2010recalled echo (GRE) imaging.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The 2D\u2010GRE and 3D\u2010SoS acquisitions were performed in 13 pediatric participants (5 healthy, 8 CF) during separate breath\u2010holds. Images from both sequences were compared on the basis of ventilation defect percent (VDP) and other measures of image similarity. The nadir of transient oxygen saturation (SpO\n                      <jats:sub>2<\/jats:sub>\n                      ) decline due to xenon breath\u2010holding was measured with pulse oximetry, and expressed as a percent change relative to baseline.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      <jats:sup>129<\/jats:sup>\n                      Xe ventilation images were acquired in a breath\u2010hold of 1.2\u20131.8\u00a0s with the 3D\u2010SoS sequence, compared to 6.2\u20138.8\u00a0s for 2D\u2010GRE. Mean\u2009\u00b1\u2009SD VDP measures for 2D\u2010GRE and 3D\u2010SoS sequences were 5.02\u2009\u00b1\u20091.06% and 5.28\u2009\u00b1\u20091.08% in healthy participants, and 18.05\u2009\u00b1\u20098.26% and 18.75\u2009\u00b1\u20096.74% in CF participants, respectively. Across all participants, the intraclass correlation coefficient of VDP measures for both sequences was 0.98 (95% confidence interval: 0.94\u20130.99). The percent change in SpO\n                      <jats:sub>2<\/jats:sub>\n                      was reduced to \u22122.1\u2009\u00b1\u20092.7% from \u22125.2\u2009\u00b1\u20093.5% with the shorter 3D\u2010SoS breath\u2010hold.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Hyperpolarized\n                      <jats:sup>129<\/jats:sup>\n                      Xe ventilation imaging with 3D\u2010SoS yielded images approximately five times faster than conventional 2D\u2010GRE, reducing SpO\n                      <jats:sub>2<\/jats:sub>\n                      desaturation and improving tolerability of the xenon administration. Analysis of VDP and other measures of image similarity demonstrate excellent agreement between images obtained with both sequences. 3D\u2010SoS holds significant potential for reducing the acquisition time of hyperpolarized\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI, and\/or increasing spatial resolution while adhering to clinical breath\u2010hold constraints.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.29505","type":"journal-article","created":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T09:28:13Z","timestamp":1669454893000},"page":"1083-1091","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["A\n                    <scp>3D stack\u2010of\u2010spirals<\/scp>\n                    approach for rapid hyperpolarized\n                    <scp>\n                      <sup>129<\/sup>\n                      Xe\n                    <\/scp>\n                    ventilation mapping in pediatric cystic fibrosis lung disease"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5645-0180","authenticated-orcid":false,"given":"Brandon","family":"Zanette","sequence":"first","affiliation":[{"name":"Translational Medicine Program The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-6234","authenticated-orcid":false,"given":"Samal","family":"Munidasa","sequence":"additional","affiliation":[{"name":"Translational Medicine Program The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario 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