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The B<jats:sub>0<\/jats:sub>\u2010dependent and B<jats:sub>1<\/jats:sub><jats:sup>+<\/jats:sup>\u2010dependent data needed for deconvolving these confounding effects would increase the scan time substantially, leading to other issues such as patient tolerability. Here, we demonstrate the feasibility of brain lipid mapping using an easily implementable transient NOE (tNOE) approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This 7T study used a frequency\u2010selective inversion pulse at a range of frequency offsets between 1.0 and 5.0 parts per million (ppm) and \u22125.0 and \u22121.0 ppm relative to bulk water peak. This was followed by a fixed\/variable mixing time and then a single\u2010shot 2D turbo FLASH readout. The feasibility of tNOE measurements is demonstrated on bovine serum albumin phantoms and healthy human brains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The tNOE measurements from bovine serum albumin phantoms were found to be independent of physiological pH variations. Both bovine serum albumin phantoms and human brains showed broad tNOE contributions centered at approximately \u22123.5\u2009ppm relative to water peak, with presumably aliphatic moieties in lipids and proteins being the dominant contributors. Less prominent tNOE contributions of approximately +2.5\u2009ppm relative to water, presumably from aromatic moieties, were also detected. These aromatic signals were free from any CEST signals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In this study, we have demonstrated the feasibility of tNOE in human brain at 7\u2009T. This method is more scan\u2010time efficient than steady\u2010state NOE and provides NOE measurement with minimal confounders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29519","type":"journal-article","created":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T06:16:24Z","timestamp":1668406584000},"page":"1357-1367","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Feasibility of transient nuclear Overhauser effect imaging in brain at 7 T"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1617-6399","authenticated-orcid":false,"given":"Dushyant","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Radiology University of Pennsylvania   Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-4164","authenticated-orcid":false,"given":"Blake","family":"Benyard","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania   Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6436-7299","authenticated-orcid":false,"given":"Narayan Datt","family":"Soni","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania   Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania   Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Wilson","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania   Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravinder","family":"Reddy","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pennsylvania   Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,13]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-007-0060-1"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/jn.109.114884"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0952-3278(95)90010-1"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-011-4882-x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.06.004"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.04.023"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000363515"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10312"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-01084-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2009.08.001"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2014.08.025"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2009.08.011"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2008.07.003"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02815156"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10863-015-9600-5"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2013.03.047"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.02.040"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26396"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3716"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4017"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24756"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-16-2265"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02839713"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6565(01)00042-5"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6565(97)00012-5"},{"key":"e_1_2_7_27_1","first-page":"221","article-title":"Chemically relayed nuclear overhauser effects. 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