{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:24Z","timestamp":1786978224666,"version":"build-2736575974"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T00:00:00Z","timestamp":1672185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["MOP 123431"],"award-info":[{"award-number":["MOP 123431"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["PJT 153099"],"award-info":[{"award-number":["PJT 153099"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["WOODS19A0"],"award-info":[{"award-number":["WOODS19A0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["RGPIN 217015\u20102013"],"award-info":[{"award-number":["RGPIN 217015\u20102013"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The purpose of this study is to assess the intra\u2010 and interscan repeatability of free\u2010breathing phase\u2010resolved functional lung (PREFUL) MRI in stable pediatric cystic fibrosis (CF) lung disease in comparison to static breath\u2010hold hyperpolarized 129\u2010xenon MRI (Xe\u2010MRI) and pulmonary function tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Free\u2010breathing 1\u2010hydrogen MRI and Xe\u2010MRI were acquired from 15 stable pediatric CF patients and seven healthy age\u2010matched participants on two visits, 1\u2009month apart. Same\u2010visit MRI scans were also performed on a subgroup of the CF patients. Following the PREFUL algorithm, regional ventilation (RVent) and regional flow volume loop cross\u2010correlation maps were determined from the free\u2010breathing data. Ventilation defect percentage (VDP) was determined from RVent maps (VDP\n                      <jats:sub>RVent<\/jats:sub>\n                      ), regional flow volume loop cross\u2010correlation maps (VDP\n                      <jats:sub>CC<\/jats:sub>\n                      ), VDP\n                      <jats:sub>RVent<\/jats:sub>\n                      \u222a VDP\n                      <jats:sub>CC<\/jats:sub>\n                      , and multi\u2010slice Xe\u2010MRI. Repeatability was evaluated using Bland\u2013Altman analysis, coefficient of repeatability (CR), and intraclass correlation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Minimal bias and no significant differences were reported for all PREFUL MRI and Xe\u2010MRI VDP parameters between intra\u2010 and intervisits (all\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&gt;\u20090.05). Repeatability of VDP\n                      <jats:sub>RVent<\/jats:sub>\n                      , VDP\n                      <jats:sub>CC<\/jats:sub>\n                      , VDP\n                      <jats:sub>RVent<\/jats:sub>\n                      \u222a VDP\n                      <jats:sub>CC<\/jats:sub>\n                      , and multi\u2010slice Xe\u2010MRI were lower between the two\u2010visit scans (CR\u00a0=\u00a014.81%, 15.36%, 16.19%, and 9.32%, respectively) in comparison to the same\u2010day scans (CR\u00a0=\u00a03.38%, 2.90%, 1.90%, and 3.92%, respectively). pulmonary function tests showed high interscan repeatability relative to PREFUL MRI and Xe\u2010MRI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PREFUL MRI, similar to Xe\u2010MRI, showed high intravisit repeatability but moderate intervisit repeatability in CF, which may be due to inherent disease instability, even in stable patients. Thus, PREFUL MRI may be considered a suitable outcome measure for future treatment response studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.29566","type":"journal-article","created":{"date-parts":[[2022,12,28]],"date-time":"2022-12-28T08:06:23Z","timestamp":1672214783000},"page":"2048-2061","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Inter\u2010 and intravisit repeatability of\n                    <scp>free\u2010breathing<\/scp>\n                    MRI in pediatric cystic fibrosis lung disease"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5948-6234","authenticated-orcid":false,"given":"Samal","family":"Munidasa","sequence":"first","affiliation":[{"name":"Translational Medicine Program The Hospital for Sick Children  Toronto Ontario Canada"},{"name":"Department of Medical Biophysics University of Toronto  Toronto Ontario 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