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These DWI acquisitions were run at 3 T under similar nominal spatial resolutions and diffusion\u2010weighting b\u2010values as used in EPI\u2010based clinical studies. Prostates of 11 patients suspected of clinically significant prostate cancer lesions were therefore scanned using the two methods, with the same number of slices, same slice thickness, and same interslice gaps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 11 patients scanned, SPEN and EPI provided comparable information in 7 of the cases, whereas EPI was deemed superior in a case for which SPEN images had to be acquired with a shorter effective TR owing to scan\u2010time constraints. SPEN provided reduced susceptibility to field\u2010derived distortions in 3 of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>SPEN's ability to provide prostate lesion contrast was most clearly evidenced for DW images acquired with b\u2009\u2265\u2009900\u2009s\/mm<jats:sup>2<\/jats:sup>. SPEN also succeeded in decreasing occasional image distortions in regions close to the rectum, affected by field inhomogeneities. EPI advantages arose when using short effective TRs, a regime in which SPEN\u2010based DWI was handicapped by its use of nonselective spin inversions, leading to the onset of an additional T<jats:sub>1<\/jats:sub> weighting.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29641","type":"journal-article","created":{"date-parts":[[2023,4,3]],"date-time":"2023-04-03T14:41:40Z","timestamp":1680532900000},"page":"643-654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prostate lesions characterization using diffusion\u2010weighted spatiotemporal encoded <scp>MRI<\/scp>: Feasibility and initial assessment"],"prefix":"10.1002","volume":"90","author":[{"given":"Martins","family":"Otikovs","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Physics Weizmann Institute of Science Rehovot 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