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Twelve\u2010week normal CD1 mice were used as controls. Post\u2010mortem paraffin tissue sections were stained using hematoxylin and eosin and picrosirius red to identify histological changes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Histology detected segmental cyst formation in the early stage (week 5) and progression of PKD over time in Pcy kidneys. In \u2010weighted images, small cysts appeared locally in cystic kidneys in week 5 and gradually extended to the whole cortex and outer stripe of outer medulla region from week 5 to week 26. Regional PSR, , , and  decreased consistently over time compared to normal kidneys, with significant changes detected in week 5. Among all the MRI measures,  and  allow highest detectability to PKD, while PSR and  have highest correlation with pathological indices of PKD. Using optimum MRI parameters as regressors, multiple linear regression provides reliable prediction of PKD progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>, , and PSR are sensitive indicators of the presence of PKD. Multiparametric MRI allows a comprehensive analysis of renal changes caused by cyst formation and expansion.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29679","type":"journal-article","created":{"date-parts":[[2023,4,24]],"date-time":"2023-04-24T17:00:53Z","timestamp":1682355653000},"page":"1151-1165","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Severity of polycystic kidney disease revealed by multiparametric <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8965-7708","authenticated-orcid":false,"given":"Feng","family":"Wang","sequence":"first","affiliation":[{"name":"Vanderbilt University Institute of Imaging Science Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Department of Radiology and Radiological Sciences Vanderbilt University Medical Center  Nashville Tennessee USA"},{"name":"Vanderbilt O'Brien Kidney Research Center 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