{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T11:08:28Z","timestamp":1781176108402,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41EB029460"],"award-info":[{"award-number":["P41EB029460"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG063896"],"award-info":[{"award-number":["R01AG063896"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG071725"],"award-info":[{"award-number":["R01AG071725"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R56AG062665"],"award-info":[{"award-number":["R56AG062665"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>Nuclear Overhauser effect magnetization transfer ratio (NOE<jats:sub>MTR<\/jats:sub>) is a technique used to investigate brain lipids and macromolecules in greater detail than other techniques and benefits from increased contrast at 7\u2009T. However, this contrast can become degraded because of  inhomogeneities present at ultra\u2010high field strengths. High\u2010permittivity dielectric pads (DP) have been used to correct for these inhomogeneities via displacement currents generating secondary magnetic fields. The purpose of this work is to demonstrate that dielectric pads can be used to mitigate  inhomogeneities and improve NOE<jats:sub>MTR<\/jats:sub> contrast in the temporal lobes at 7\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Partial 3D NOE<jats:sub>MTR<\/jats:sub> contrast images and whole brain  field maps were acquired on a 7\u2009T MRI across six healthy subjects. Calcium titanate DP, having a relative permittivity of 110, was placed next to the subject's head near the temporal lobes. Pad corrected NOE<jats:sub>MTR<\/jats:sub> images had a separate postprocessing linear correction applied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DP provided supplemental  to the temporal lobes while also reducing the  magnitude across the posterior and superior regions of the brain. This resulted in a statistically significant increase in NOE<jats:sub>MTR<\/jats:sub> contrast in substructures of the temporal lobes both with and without linear correction. The padding also produced a convergence in NOE<jats:sub>MTR<\/jats:sub> contrast toward approximately equal mean values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>NOE<jats:sub>MTR<\/jats:sub> images showed significant improvement in temporal lobe contrast when DP were used, which resulted from an increase in  homogeneity across the entire brain slab. DP\u2010derived improvements in NOE<jats:sub>MTR<\/jats:sub> are expected to increase the robustness of the brain substructural measures both in healthy and pathological conditions.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29739","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T12:27:44Z","timestamp":1686140864000},"page":"1537-1546","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["B1+$$ {\\mathrm{B}}_1^{+} $$ inhomogeneity correction of volumetric brain <scp>NOE<sub>MTR<\/sub><\/scp> via high permittivity dielectric padding at <scp>7\u2009T<\/scp>"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-4010","authenticated-orcid":false,"given":"Paul S.","family":"Jacobs","sequence":"first","affiliation":[{"name":"Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2480-4164","authenticated-orcid":false,"given":"Blake","family":"Benyard","sequence":"additional","affiliation":[{"name":"Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quy","family":"Cao","sequence":"additional","affiliation":[{"name":"Penn Statistics in Imaging and Visualization Center, Department of Biostatistics, Epidemiology, and Informatics University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anshuman","family":"Swain","sequence":"additional","affiliation":[{"name":"Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Wilson","sequence":"additional","affiliation":[{"name":"Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3644-5656","authenticated-orcid":false,"given":"Ravi Prakash Reddy","family":"Nanga","sequence":"additional","affiliation":[{"name":"Center for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0454-3112","authenticated-orcid":false,"given":"M. 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