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Firstly, a bi\u2010exponential tensor model was fitted separately at each diffusion time to disentangle the dependence on diffusion times from diffusion weightings, that is, b\u2010values. The slow\u2010diffusing component was attributed to the restricted diffusion inside cardiomyocytes. ICV was then extrapolated at  using linear regression. Secondly, given the secondary and the tertiary diffusion eigenvalue measurements for the slow\u2010diffusing component obtained at different diffusion times, major and minor diameters were estimated assuming a cylinder model with an elliptical cross\u2010section (ECS). High\u2010resolution three\u2010dimensional synchrotron X\u2010ray imaging (SRI) data from the same specimen was utilized to evaluate the biophysical parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estimated parameters using DWI data were (control 1\/control 2 vs. TAC 1\/TAC 2): major diameter\u201417.4 m\/18.0 m versus 19.2 m\/19.0 m; minor diameter\u201410.2 m\/9.4 m versus 12.8 m\/13.4 m; and ICV\u201462%\/62% versus 68%\/47%. These findings were consistent with SRI measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The proposed method allowed for accurate estimation of biophysical parameters suggesting cardiomyocyte diameters as sensitive biomarkers of hypertrophy in the heart.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29775","type":"journal-article","created":{"date-parts":[[2023,6,24]],"date-time":"2023-06-24T18:31:10Z","timestamp":1687631470000},"page":"2144-2157","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Measuring cardiomyocyte cellular characteristics in cardiac hypertrophy using diffusion\u2010weighted MRI"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4663-2110","authenticated-orcid":false,"given":"Mohsen","family":"Farzi","sequence":"first","affiliation":[{"name":"Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7134-3196","authenticated-orcid":false,"given":"Sam","family":"Coveney","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds  Leeds UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3378-0878","authenticated-orcid":false,"given":"Maryam","family":"Afzali","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Science Department, Leeds Institute of Cardiovascular and Metabolic Medicine University of Leeds  Leeds UK"},{"name":"Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology Cardiff University  Cardiff UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Christine","family":"Zdora","sequence":"additional","affiliation":[{"name":"Diamond Light Source Ltd. 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