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The purpose of this work was to design a fast T<jats:sub>2<\/jats:sub>\u2010weighted sequence capable of simultaneously acquiring two orthogonal slices, enabling real\u2010time tracking of lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To generate a T<jats:sub>2<\/jats:sub> contrast in two orthogonal slices simultaneously, a sequence (Ortho\u2010SFFP\u2010Echo) was designed that samples the T<jats:sub>2<\/jats:sub>\u2010weighted spin echo (<jats:italic>S<\/jats:italic><jats:sup>\u2212<\/jats:sup>) signal in a TR\u2010interleaved acquisition of two slices. Slice selection and phase\u2010encoding directions are swapped between the slices, leading to a unique set of spin\u2010echo signal conditions. To minimize motion\u2010related signal dephasing, additional flow\u2010compensation strategies are implemented. In both the abdominal breathing phantom and in vivo experiments, a time series was acquired using Ortho\u2010SSFP\u2010Echo. The centroid of the target was tracked in postprocessing steps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the phantom, the lesion could be identified and delineated in the dynamic images. In the volunteer experiments, the kidney was visualized with a T<jats:sub>2<\/jats:sub> contrast at a temporal resolution of 0.45\u2009s under free\u2010breathing conditions. A respiratory belt demonstrated a strong correlation with the time course of the kidney centroid in the head\u2013foot direction. A hypointense saturation band at the slice overlap did not inhibit lesion tracking in the semi\u2010automatic postprocessing steps.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The Ortho\u2010SFFP\u2010Echo sequence delivers real\u2010time images with a T<jats:sub>2<\/jats:sub>\u2010weighted contrast in two orthogonal slices. The sequence allows for simultaneous acquisition, which could be beneficial for real\u2010time motion tracking in radiotherapy or interventional MRI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29795","type":"journal-article","created":{"date-parts":[[2023,7,10]],"date-time":"2023-07-10T08:56:25Z","timestamp":1688979385000},"page":"2388-2399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Simultaneous <scp>T<sub>2<\/sub><\/scp>\u2010weighted real\u2010time <scp>MRI<\/scp> of two orthogonal\u00a0slices"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7036-4112","authenticated-orcid":false,"given":"Samantha","family":"Hickey","sequence":"first","affiliation":[{"name":"Division of Medical Physics, Department of Diagnostic and Interventional Radiology, University Medical Center Freiburg, Faculty of Medicine University of Freiburg  Freiburg 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