{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:11Z","timestamp":1786978391113,"version":"build-2736575974"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["713406"],"award-info":[{"award-number":["713406"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 HL146689"],"award-info":[{"award-number":["R01 HL146689"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005627","name":"Thrasher Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005627","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>\n                      The underlying functional and microstructural lung disease in neonates who are born preterm (bronchopulmonary dysplasia, BPD) remains poorly characterized. Moreover, there is a lack of suitable techniques to reliably assess lung function in this population. Here, we report our preliminary experience with hyperpolarized\n                      <jats:sup>129<\/jats:sup>\n                      Xe MRI in neonates with BPD.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Neonatal intensive care patients with established BPD were recruited (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u20099) and imaged at a corrected gestational age of median:40.7 (range:37.1, 44.4) wk using a 1.5T neonatal scanner. 2D\n                      <jats:sup>129<\/jats:sup>\n                      Xe ventilation and diffusion\u2010weighted images and dissolved phase spectroscopy were acquired, alongside\n                      <jats:sup>1<\/jats:sup>\n                      H 3D radial UTE.\n                      <jats:sup>129<\/jats:sup>\n                      Xe images were acquired during a series of short apneic breath\u2010holds (\u02dc3\u2009s).\n                      <jats:sup>1<\/jats:sup>\n                      H UTE images were acquired during tidal breathing. Ventilation defects were manually identified and qualitatively compared to lung structures on UTE. ADCs were calculated on a voxel\u2010wise basis. The signal ratio of the\n                      <jats:sup>129<\/jats:sup>\n                      Xe red blood cell (RBC) and tissue membrane (M) resonances from spectroscopy was determined.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Spiral\u2010based\n                      <jats:sup>129<\/jats:sup>\n                      Xe ventilation imaging showed good image quality and sufficient sensitivity to detect mild ventilation abnormalities in patients with BPD.\n                      <jats:sup>129<\/jats:sup>\n                      Xe ADC values were elevated above that expected given healthy data in older children and adults (median:0.046 [range:0.041, 0.064] cm\n                      <jats:sup>2<\/jats:sup>\n                      s\n                      <jats:sup>\u22121<\/jats:sup>\n                      ); the highest value obtained from an extremely pre\u2010term patient.\n                      <jats:sup>129<\/jats:sup>\n                      Xe spectroscopy revealed a low RBC\/M ratio (0.14 [0.06, 0.21]).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      We have demonstrated initial feasibility of\n                      <jats:sup>129<\/jats:sup>\n                      Xe lung MRI in neonates. With further data, the technique may help guide management of infant lung diseases in the neonatal period and beyond.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.29808","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T05:00:33Z","timestamp":1690866033000},"page":"2420-2431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Initial feasibility and challenges of hyperpolarized\n                    <scp>\n                      <sup>129<\/sup>\n                      Xe\n                    <\/scp>\n                    MRI in neonates with bronchopulmonary dysplasia"],"prefix":"10.1002","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8358-394X","authenticated-orcid":false,"given":"Neil J.","family":"Stewart","sequence":"first","affiliation":[{"name":"Center for Pulmonary Imaging Research, Pulmonary Medicine and Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"POLARIS, Imaging Sciences, Department of Infection, Immunity &amp; Cardiovascular Disease University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6233-161X","authenticated-orcid":false,"given":"Nara S.","family":"Higano","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Pulmonary Medicine and Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanmukha","family":"Mukthapuram","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"The Perinatal Institute, Section of Neonatology, Perinatal and Pulmonary Biology, Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-9622","authenticated-orcid":false,"given":"Matthew M.","family":"Willmering","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Pulmonary Medicine and Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Loew","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"West","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Pulmonary Medicine and Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Arnsperger","sequence":"additional","affiliation":[{"name":"Division of Respiratory Care Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Pratt","sequence":"additional","affiliation":[{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhwesha R.","family":"Rao","sequence":"additional","affiliation":[{"name":"POLARIS, Imaging Sciences, Department of Infection, Immunity &amp; Cardiovascular Disease University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rolf F.","family":"Schulte","sequence":"additional","affiliation":[{"name":"GE Healthcare  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7246-8660","authenticated-orcid":false,"given":"Jim M.","family":"Wild","sequence":"additional","affiliation":[{"name":"POLARIS, Imaging Sciences, Department of Infection, Immunity &amp; Cardiovascular Disease University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8080-7511","authenticated-orcid":false,"given":"Jason C.","family":"Woods","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Pulmonary Medicine and Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"},{"name":"Department of Pediatrics University of Cincinnati College of Medicine  Cincinnati Ohio USA"},{"name":"Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0127-7"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199012273232603"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12633-5"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-1423"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2013.311"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26212"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25643"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201711-2287OC"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28165"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247\u2010023\u201005598\u20106"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20210207"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.07.008"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.11102172"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210070"},{"key":"e_1_2_7_16_1","unstructured":"AltesTA MataJ FrohDK Paget\u2010BrownA deLangeEE MuglerJP.Abnormalities of Lung Structure in Children with Bronchopulmonary Dysplasia as Assessed by Diffusion Hyperpolarized Helium\u20103 MRI. International Society for Magnetic Resonance in Medicine Annual Meeting Seattle.2006#86."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/RTI.0000000000000244"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202203-0606OC"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinimag.2017.04.004"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201812-2348OC"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-012-2444-9"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.13.10613"},{"key":"e_1_2_7_23_1","first-page":"3563","article-title":"A 129Xe\/1H switched frequency high pass birdcage coil for hyperpolarized 129Xe gas lung imaging in neonates at 1.5 T","author":"Pratt R","year":"2021","journal-title":"Int Soc Mag Reson Med"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmr.b.21309"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10303"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23056"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26960"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511084"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4029"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20631"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10477"},{"key":"e_1_2_7_32_1","first-page":"4000","volume-title":"Proc Intl Soc Mag Reson Med. 20","author":"Marshall H","year":"2012"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25394"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2005.848376"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-38981-1"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24992"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00831-2019"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/jp.2014.154"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-016-3672-1"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202001-0031LE"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2016-208948"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.00324-2018"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01133.2007"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1084-2756(02)00193-8"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28136"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a011643"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26745"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28385"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24219"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.1697"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2018.07.017"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28985"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.29808","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:57:17Z","timestamp":1695995837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.29808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":51,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1002\/mrm.29808"],"URL":"https:\/\/doi.org\/10.1002\/mrm.29808","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-03-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}