{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:52:07Z","timestamp":1767034327714,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To develop prospective motion correction for single\u2010voxel MRS in the human cervical spinal cord.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A motion MR navigator was implemented using reduced field\u2010of\u2010view 2D\u2010selective RF excitation together with EPI readout. A short\u2010echo semi\u2010LASER sequence (T<jats:sub>E<\/jats:sub>\u2009=\u200930\u2009ms) was updated to incorporate this real\u2010time image\u2010based motion navigator, as well as real\u2010time shim and frequency navigators. Five healthy participants were studied at 3\u2009T with a 64\u2010channel head\u2013neck receive coil. Single\u2010voxel MRS data were measured in a voxel located at the C3\u20105 vertebrae level. The motion navigator was used to correct for translations in the <jats:italic>X<\/jats:italic>\u2010<jats:italic>Y<\/jats:italic> plane and was validated by assessing spectral quality with and without prospective correction in the presence of subject motion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Without prospective correction, motion resulted in severe lipid contamination in the MR spectra. With prospective correction, the quality of spinal cord MR spectra in the presence of motion was similar to that obtained in the absence of motion, with comparable spectral signal\u2010to\u2010noise ratio and linewidth and no significant lipid contamination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Prospective motion and <jats:italic>B<\/jats:italic><jats:sub>0<\/jats:sub> correction allow acquisition of good\u2010quality MR spectra in the human cervical spinal cord in the presence of motion. This new technique should facilitate reliable acquisition of spinal cord MR spectra in both research and clinical settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29836","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:19:35Z","timestamp":1695986375000},"page":"19-27","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prospective motion correction for cervical spinal cord MRS"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1402-5877","authenticated-orcid":false,"given":"Isaac M.","family":"Adanyeguh","sequence":"first","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre\u2010Gilles","family":"Henry","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4266-4780","authenticated-orcid":false,"given":"Dinesh K.","family":"Deelchand","sequence":"additional","affiliation":[{"name":"Center for Magnetic Resonance Research, Department of Radiology University of Minnesota  Minneapolis Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2012.09.009"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A3342"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2867"},{"key":"e_1_2_9_5_1","unstructured":"HenryPG JoersJM DeelchandDK et al.Longitudinal MRS MRI and DTI of the spinal cord in Friedreich's ataxia. In Proceedings of the 25th Annual Meeting of ISMRM Honolulu HI 2017. p.921."},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20084"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21382"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.03811"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcac246"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXG.0000000000200034"},{"key":"e_1_2_9_11_1","first-page":"1069","article-title":"Single voxel 1H\u2010MR spectroscopy in the human spinal cord at 3T \u2010preliminary results","volume":"8","author":"Wawrzyniak P","year":"2021","journal-title":"Austin J Med Oncol"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3487"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27886"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.22805"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24129"},{"key":"e_1_2_9_16_1","unstructured":"FinsterbuschJ.Multi\u2010band\u2010accelerated T2*\u2010weighted inner\u2010field\u2010of\u2010view EPI of the human spinal cord with slice\u2010specific z\u2010shimming. In Proceedings of the 26th Annual Meeting of ISMRM Paris France 2018. p.5448."},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.10157"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21717"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25897"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1364\/OL.33.000156"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4218"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20549"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1999.1713"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24387"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26788"},{"key":"e_1_2_9_26_1","unstructured":"DeelchandDK.MRspa: Magnetic Resonance signal processing and analysis. August2018 versionhttps:\/\/www.cmrr.umn.edu\/downloads\/mrspa\/"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910300604"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25295"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23080"},{"key":"e_1_2_9_30_1","unstructured":"DeelchandDK HenryP\u2010G.Effect of water suppression and metabolite cycling on quantification of 1H MRS spectra in the human brain at 3 Tesla. In Proceedings of the 26th Annual Meeting of ISMRM Paris France 2018. p.2895."},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25075"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2017.11.031"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.09.038"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.2852"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21578"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29182"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1203"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.29836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T13:58:04Z","timestamp":1705499884000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.29836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,29]]},"references-count":36,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/mrm.29836"],"URL":"https:\/\/doi.org\/10.1002\/mrm.29836","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"type":"print","value":"0740-3194"},{"type":"electronic","value":"1522-2594"}],"subject":[],"published":{"date-parts":[[2023,9,29]]},"assertion":[{"value":"2023-05-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}