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However, quantifying guanidinium CEST is challenging due to multiple overlapping components and a close frequency offset from water. This study aims to evaluate the applicability of a new rapid and model\u2010free CEST quantification method using double saturation power, termed DSP\u2010CEST, for isolating the guanidinium CEST effect from confounding factors in ischemia. To further reduce acquisition time, the DSP\u2010CEST was combined with a quasi\u2010steady state (QUASS) CEST technique to process non\u2010steady\u2010state CEST signals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The specificity and accuracy of the DSP\u2010CEST method in quantifying the guanidinium CEST effect were assessed by comparing simulated CEST signals with\/without the contribution from confounding factors. The feasibility of this method for quantifying guanidinium CEST was evaluated in a rat model of global ischemia induced by cardiac arrest and compared to a conventional multiple\u2010pool Lorentzian fit method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The DSP\u2010CEST method was successful in removing all confounding components and quantifying the guanidinium CEST signal increase in ischemia. This suggests that the DSP\u2010CEST has the potential to provide hyperintense contrast in stroke lesions. Additionally, the DSP\u2010CEST was shown to be a rapid method that does not require the acquisition of the entire or a portion of the CEST Z\u2010spectrum that is required in conventional model\u2010based fitting approaches.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study highlights the potential of DSP\u2010CEST as a valuable tool for rapid and specific detection of viable tissues.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.29960","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T07:43:37Z","timestamp":1702626217000},"page":"1512-1527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Specific and rapid guanidinium <scp>CEST<\/scp> imaging using double saturation power and <scp>QUASS<\/scp> analysis in a rodent model of global ischemia"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4351-7398","authenticated-orcid":false,"given":"Iris Y.","family":"Zhou","sequence":"first","affiliation":[{"name":"Athinoula A. 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