{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T16:20:18Z","timestamp":1756311618382,"version":"3.40.5"},"reference-count":57,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T00:00:00Z","timestamp":1707177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SFB 1365","(394046635)"],"award-info":[{"award-number":["SFB 1365","(394046635)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>The increasing incidence of kidney diseases is a global concern, and current biomarkers and treatments are inadequate. Changes in renal tubule luminal volume fraction (TVF) serve as a rapid biomarker for kidney disease and improve understanding of renal (patho)physiology. This study uses the amplitude of the long T<jats:sub>2<\/jats:sub> component as a surrogate for TVF in rats, by applying multiexponential analysis of the T<jats:sub>2<\/jats:sub>\u2010driven signal decay to examine micromorphological changes in renal tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Simulations were conducted to identify a low mean absolute error (MAE) protocol and an accelerated protocol customized for the in vivo study of T<jats:sub>2<\/jats:sub> mapping of the rat kidney at 9.4\u2009T. We then validated our bi\u2010exponential approach in a phantom mimicking the relaxation properties of renal tissue. This was followed by a proof\u2010of\u2010principle demonstration using in vivo data obtained during a transient increase of renal pelvis and tubular pressure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using the low MAE protocol, our approach achieved an accuracy of MAE\u2009&lt;\u20091% on the mechanical phantom. The T<jats:sub>2<\/jats:sub> mapping protocol customized for in vivo study achieved an accuracy of MAE &lt;\u20093%. Transiently increasing pressure in the renal pelvis and tubules led to significant changes in TVF in renal compartments: \u0394TVF<jats:sub>cortex<\/jats:sub>\u2009=\u20094.9%, \u0394TVF<jats:sub>outer_medulla<\/jats:sub>\u2009=\u20094.5%, and \u0394TVF<jats:sub>inner_medulla<\/jats:sub>\u2009=\u2009\u221214.6%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results demonstrate that our approach is promising for research into quantitative assessment of renal TVF in in vivo applications. Ultimately, these investigations have the potential to help reveal mechanism in acute renal injury that may lead to chronic kidney disease, which will support research into renal disorders.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30023","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T08:50:37Z","timestamp":1707295837000},"page":"2532-2545","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["In vivo monitoring of renal tubule volume fraction using dynamic parametric <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4190-7202","authenticated-orcid":false,"given":"Ehsan","family":"Tasbihi","sequence":"first","affiliation":[{"name":"Berlin Ultrahigh Field Facility Max Delbrueck Center for Molecular Medicine in the Helmholtz Association  Berlin Germany"},{"name":"Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Gladytz","sequence":"additional","affiliation":[{"name":"Berlin Ultrahigh Field Facility Max Delbrueck Center for Molecular Medicine in the Helmholtz Association  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason M.","family":"Millward","sequence":"additional","affiliation":[{"name":"Berlin Ultrahigh Field Facility Max Delbrueck Center for Molecular Medicine in the Helmholtz Association  Berlin Germany"},{"name":"Hasso Plattner Institute for Digital Engineering University of Potsdam  Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u0101o S.","family":"Periquito","sequence":"additional","affiliation":[{"name":"Berlin Ultrahigh Field Facility Max Delbrueck Center for Molecular Medicine in the Helmholtz Association  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0359-0101","authenticated-orcid":false,"given":"Ludger","family":"Starke","sequence":"additional","affiliation":[{"name":"Berlin Ultrahigh Field Facility Max Delbrueck Center for Molecular Medicine in the Helmholtz Association  Berlin Germany"},{"name":"Experimental and Clinical Research Center, a Joint Cooperation Between the Charit\u00e9 Medical Faculty and the Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9916-9572","authenticated-orcid":false,"given":"Sonia","family":"Waiczies","sequence":"additional","affiliation":[{"name":"Berlin Ultrahigh Field Facility Max Delbrueck Center for Molecular Medicine in the Helmholtz Association  Berlin Germany"},{"name":"Hasso Plattner Institute for Digital Engineering University of Potsdam  Potsdam Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Cantow","sequence":"additional","affiliation":[{"name":"Institute of Translational Physiology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erdmann","family":"Seeliger","sequence":"additional","affiliation":[{"name":"Institute of Translational Physiology Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thoralf","family":"Niendorf","sequence":"additional","affiliation":[{"name":"Berlin Ultrahigh Field Facility Max Delbrueck Center for Molecular Medicine in the Helmholtz Association  Berlin Germany"},{"name":"Experimental and Clinical Research Center, a Joint Cooperation Between the Charit\u00e9 Medical Faculty and the Max Delbr\u00fcck Center for Molecular Medicine  Berlin Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,2,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1977.118"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V102366"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577\u2010022\u201000816\u2010y"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2019.0580"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66583-X"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfr275"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvs.2010.01.049"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.184"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2016060666"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010018\u20101822\u20100"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.196"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr494"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/end.2018.0667"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l5919"},{"volume-title":"Urinary Tract Obstruction","year":"2022","author":"Preminger GM","key":"e_1_2_7_16_1"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345\u2010018\u20102378\u20104"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.168.2.3393671"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.21037\/qims\u201020\u20101360"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.18383\/j.tom.2016.00127"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28698"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057411"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1522\u20102594(199911)42:5<919::aid\u2010mrm12>3.0.co;2\u20108"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13701"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910040605"},{"key":"e_1_2_7_26_1","unstructured":"TasbihiE GladytzT StarkeL MillwardJM SeeligerE NiendorfT.Toward assessment of renal tubule volume fraction in rat kidney using decomposition of parametric T2 mapping. In:Proceedings of the 32nd Annual Meeting of ISMRM Toronto Ontario Canada.2023. Digital poster 4441"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006\u20103495(89)82797\u20103"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01932339"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11604\u2010022\u201001273\u20102"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1109\/tip.2015.2442917"},{"key":"e_1_2_7_31_1","doi-asserted-by":"crossref","unstructured":"JamarikJ VojtisekL SchwarzD.Uncovering cortical layers with multi\u2010exponential analysis: a region of interest study. 2022 30th European Signal Processing Conference.1353\u20131356. doi:10.23919\/eusipco55093.2022.9909806","DOI":"10.23919\/EUSIPCO55093.2022.9909806"},{"key":"e_1_2_7_32_1","doi-asserted-by":"crossref","unstructured":"YuanYX.A Review of Trust Region Algorithms for Optimization.ICM99: Proceedings of the Fourth International Congress on Industrial and Applied Mathematics.271\u2010282.","DOI":"10.1093\/oso\/9780198505143.003.0023"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-2364(88)90128-X"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/CMR.1820030302"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29286"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.23157"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20100978\u20101_36"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.596566"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13868"},{"key":"e_1_2_7_40_1","doi-asserted-by":"crossref","unstructured":"CantowK Ladwig\u2010WiegardM FlemmingB PohlmannA NiendorfT SeeligerE.Monitoring renal hemodynamics and oxygenation by invasive probes: experimental protocol. Preclinical MRI of the Kidney: Methods and Protocols. Humana Press;2021:327\u2010347. doi:10.1007\/978\u20101\u20100716\u20100978\u20101_19","DOI":"10.1007\/978-1-0716-0978-1_19"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1364\/BOE.6.000309"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20100978\u20101_3"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0b013e3182a6fea6"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplegacy.1956.185.2.430"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/RLI.0000000000000054"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12065"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20100716\u20100978\u20101_33"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics12071626"},{"key":"e_1_2_7_49_1","unstructured":"KassambaraA.rstatix: Pipe\u2010friendly framework for basic statistical tests (R package Version 0.7. 0) [Computer software].2021."},{"key":"e_1_2_7_50_1","unstructured":"Morgan\u2010WallT.rayshader: Create Maps and Visualize Data in 2D and 3D.2020. Accessed January 5 2024.https:\/\/github.com\/tylermorganwall\/rayshader"},{"key":"e_1_2_7_51_1","first-page":"1","article-title":"Package \u2018dunn. test","volume":"10","author":"Dinno A","year":"2017","journal-title":"CRAN Rep."},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11255\u2010020\u201002421\u20101"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsbiomaterials.0c01468"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587\u2010019\u20100048\u20108"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9061326"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2021.12.006"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12393"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8846622"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.30023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,5]],"date-time":"2024-04-05T10:32:47Z","timestamp":1712313167000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.30023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":57,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1002\/mrm.30023"],"URL":"https:\/\/doi.org\/10.1002\/mrm.30023","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"type":"print","value":"0740-3194"},{"type":"electronic","value":"1522-2594"}],"subject":[],"published":{"date-parts":[[2024,2,6]]},"assertion":[{"value":"2023-09-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}