{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:29Z","timestamp":1786978229189,"version":"build-2736575974"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,31]],"date-time":"2024-01-31T00:00:00Z","timestamp":1706659200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000897","name":"Cystic Fibrosis Foundation","doi-asserted-by":"publisher","award":["NAREN19R0"],"award-info":[{"award-number":["NAREN19R0"]}],"id":[{"id":"10.13039\/100000897","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01HL126771"],"award-info":[{"award-number":["2R01HL126771"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00HL138255"],"award-info":[{"award-number":["R00HL138255"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL131012"],"award-info":[{"award-number":["R01HL131012"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL137787"],"award-info":[{"award-number":["R01HL137787"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL143011"],"award-info":[{"award-number":["R01HL143011"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL151588"],"award-info":[{"award-number":["R01HL151588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL166335"],"award-info":[{"award-number":["R01HL166335"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>Hyperpolarized xenon MRI suffers from heterogeneous coil bias and magnetization decay that obscure pulmonary abnormalities. Non\u2010physiological signal variability can be mitigated by measuring and mapping the nominal flip angle, and by rescaling the images to correct for signal bias and decay. While flip angle maps can be calculated from sequentially acquired images, scan time and breath\u2010hold duration are doubled. Here, we exploit the low\u2010frequency oversampling of 2D\u2010spiral and keyhole reconstruction to measure flip angle maps from a single acquisition.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Flip angle maps were calculated from two images generated from a single dataset using keyhole reconstructions and a Bloch\u2010equation\u2013based model suitable for hyperpolarized substances. Artifacts resulting from acquisition and reconstruction schemes (e.g., keyhole reconstruction radius, slice\u2010selection profile, spiral\u2010ordering, and oversampling) were assessed using point\u2010spread functions. Simulated flip angle maps generated using keyhole reconstruction were compared against the paired\u2010image approach using RMS error (RMSE). Finally, feasibility was demonstrated for in vivo xenon ventilation imaging.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Simulations demonstrated accurate flip angle maps and\n                      <jats:italic>B<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      \u2010inhomogeneity correction can be generated with only 1.25\u2010fold central\u2010oversampling and keyhole reconstruction radius\u2009=\u20095% (RMSE\u2009=\u20090.460\u00b0). These settings also generated accurate flip angle maps in a healthy control (RSME\u2009=\u20090.337\u00b0) and a person with cystic fibrosis (RMSE\u2009=\u20090.404\u00b0) in as little as 3.3\u2009s.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Regional lung ventilation images with reduced impact of\n                      <jats:italic>B<\/jats:italic>\n                      <jats:sub>1<\/jats:sub>\n                      \u2010inhomogeneity can be acquired rapidly by combining 2D\u2010spiral acquisition, Bloch\u2010equation\u2013based modeling, and keyhole reconstruction. This approach will be especially useful for breath\u2010hold studies where short scan durations are necessary, such as dynamic imaging and applications in children or people with severely compromised respiratory function.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30028","type":"journal-article","created":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:41:55Z","timestamp":1706748115000},"page":"967-981","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Analytical corrections for\n                    <i>B<\/i>\n                    <sub>1<\/sub>\n                    \u2010inhomogeneity and signal decay in multi\u2010slice 2D spiral hyperpolarized\n                    <sup>129<\/sup>\n                    Xe MRI using keyhole reconstruction"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0200-7869","authenticated-orcid":false,"given":"J. W.","family":"Plummer","sequence":"first","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Biomedical Engineering University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-2345","authenticated-orcid":false,"given":"R.","family":"Hussain","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-7032","authenticated-orcid":false,"given":"A. S.","family":"Bdaiwi","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Biomedical Engineering University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2954-9710","authenticated-orcid":false,"given":"M. L.","family":"Costa","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Biomedical Engineering University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4356-9622","authenticated-orcid":false,"given":"M. M.","family":"Willmering","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3596-6644","authenticated-orcid":false,"given":"J.","family":"Parra\u2010Robles","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6195-9061","authenticated-orcid":false,"given":"Z. I.","family":"Cleveland","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Biomedical Engineering University of Cincinnati  Cincinnati OH USA"},{"name":"Imaging Research Center, Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Pediatrics University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5060-6401","authenticated-orcid":false,"given":"L. L.","family":"Walkup","sequence":"additional","affiliation":[{"name":"Center for Pulmonary Imaging Research, Division of Pulmonary Medicine Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Biomedical Engineering University of Cincinnati  Cincinnati OH USA"},{"name":"Imaging Research Center, Department of Radiology Cincinnati Children's Hospital Medical Center  Cincinnati OH USA"},{"name":"Department of Pediatrics University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,31]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3151"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4639"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28985"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1148\/ryct.2021200571"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29655"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.10303"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.18103\/bme.v3i1.1550"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2021.06.017"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2010.2046908"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29254"},{"key":"e_1_2_10_12_1","unstructured":"HussainR PlummerJW BdaiwiAS WillmeringMM WalkupLL ClevelandZI.Improved Efficiency and Quantitative Accuracy in Hyperpolarized129Xe Ventilation Imaging Using 2D Spiral Acquisition. In Proceedings of the 32nd Joint ISMRM & ISMRT Annual Meeting Toronto Ontario Canada 2023. p. 4093."},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29501"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-003-0028-2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1522-2594(200012)44:6<825::AID-MRM2>3.0.CO;2-D"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4774050"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10334-003-0003-y"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27721"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.4464"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.454842"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880030419"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2016150106"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.21354"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24675"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.1986.4307732"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199908)42:2<412::AID-MRM25>3.0.CO;2-U"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(199902)41:2<417::AID-MRM29>3.0.CO;2-W"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmr.a.21352"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmr.2020.106845"},{"key":"e_1_2_10_30_1","unstructured":"OngF LustigM.SigPy: a python package for high performance iterative reconstruction. In Proceedings of the 27th Annual Meeting of ISMRM Montr\u00e9al Qu\u00e9bec Canada.2019. Abstract 4819."},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcf.2016.07.008"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910350417"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2594(200003)43:3<452::AID-MRM18>3.0.CO;2-B"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1309"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.21391"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910370416"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29505"},{"key":"e_1_2_10_38_1","unstructured":"PlummerJW BdaiwiAS SoderlundSA et al.Compressed Sense Reconstructions Improve Non\u2010Cartesian Hyperpolarized Xe MRI. In Proceedings of the 32nd Joint ISMRM & ISMRT Annual Meeting Toronto Ontario Canada 2023. p. 0856."},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29518"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27765"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.30028","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:23:41Z","timestamp":1719188621000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.30028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,31]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/mrm.30028"],"URL":"https:\/\/doi.org\/10.1002\/mrm.30028","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,31]]},"assertion":[{"value":"2023-10-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-31","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}