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The present study aims to develop a noncontrast technique to measure a novel blood flow circulatory measure, venous transit time (VTT), which denotes the time it takes for water to travel from capillary to major veins.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The proposed sequence, venous transit time imaging by changes in T<jats:sub>1<\/jats:sub> relaxation (VICTR), is based on the notion that as water molecules transition from the tissue into the veins, they undergo a change in T<jats:sub>1<\/jats:sub> relaxation time. The validity of the measured VTT was tested by studying the VTT along the anatomically known flow trajectory of venous vessels as well as using a physiological vasoconstrictive challenge of caffeine ingestion. Finally, we compared the VTT measured with VICTR MRI to a bolus\u2010tracking method using gadolinium\u2010based contrast agent.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VTT was measured to be 3116.3\u2009\u00b1\u2009326.0\u2009ms in the posterior superior sagittal sinus (SSS), which was significantly longer than 2865.0\u2009\u00b1\u2009390.8\u2009ms at the anterior superior sagittal sinus (<jats:italic>p<\/jats:italic>\u2009=\u20090.004). The test\u2013retest assessment showed an interclass correlation coefficient of 0.964. VTT was significantly increased by 513.8\u2009\u00b1\u2009239.3\u2009ms after caffeine ingestion (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). VTT measured with VICTR MRI revealed a strong correlation (<jats:italic>R<\/jats:italic>\u2009=\u20090.84, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) with that measured with the contrast\u2010based approach. VTT was found inversely correlated to cerebral blood flow and venous oxygenation across individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A noncontrast MRI technique, VICTR MRI, was developed to measure the VTT of the brain.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30051","type":"journal-article","created":{"date-parts":[[2024,2,27]],"date-time":"2024-02-27T10:59:24Z","timestamp":1709031564000},"page":"158-172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["<scp>VICTR<\/scp>: Venous transit time imaging by changes in T<sub>1<\/sub> relaxation"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5312-4889","authenticated-orcid":false,"given":"Wen","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Biomedical Engineering Johns Hopkins University School of Medicine  Baltimore Maryland USA"},{"name":"The Russell H. 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