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Diffusion weighted sequences provide a useful clinical contrast but have prolonged scan times due to low signal\u2010to\u2010noise ratio (SNR), and cannot be completed in a single breath hold. Echo\u2010planar imaging (EPI) is the most commonly used trajectory for diffusion weighted imaging but it is susceptible to off\u2010resonance artifacts. A respiratory resolved, three\u2010dimensional (3D) diffusion prepared sequence that obtains distortionless diffusion weighted images during free\u2010breathing is presented. Techniques to address the myriad of challenges including: 3D shot\u2010to\u2010shot phase correction, respiratory binning, diffusion encoding during free\u2010breathing, and robustness to off\u2010resonance are described.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A twice\u2010refocused, M1\u2010nulled diffusion preparation was combined with an RF\u2010spoiled gradient echo readout and respiratory resolved reconstruction to obtain free\u2010breathing diffusion weighted images in the abdomen. Cartesian sampling permits a sampling density that enables 3D shot\u2010to\u2010shot phase navigation and reduction of transient fat artifacts. Theoretical properties of a region\u2010based shot rejection are described. The region\u2010based shot rejection method was evaluated with free\u2010breathing (normal and exaggerated breathing), and respiratory triggering. The proposed sequence was compared in vivo with multishot DW\u2010EPI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The proposed sequence exhibits no evident distortion in vivo when compared to multishot DW\u2010EPI, robustness to B0 and B1 field inhomogeneities, and robustness to motion from different respiratory patterns.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Acquisition of distortionless, diffusion weighted images is feasible during free\u2010breathing with a b\u2010value of 500 s\/mm<jats:sup>2<\/jats:sup>, scan time of 6 min, and a clinically viable reconstruction time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30067","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T02:35:12Z","timestamp":1714530912000},"page":"586-604","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Distortionless, free\u2010breathing, and 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