{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:38:15Z","timestamp":1790872695031,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG072490"],"award-info":[{"award-number":["RF1AG072490"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["A20201411S"],"award-info":[{"award-number":["A20201411S"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS118019"],"award-info":[{"award-number":["R01NS118019"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Directly imaging the function of cerebral perforating arteries could provide valuable insight into the pathology of cerebral small vessel diseases (cSVD). Arterial pulsatility has been identified as a useful biomarker for assessing vascular dysfunction. In this study, we investigate the feasibility and reliability of using dual velocity encoding (VENC) phase\u2010contrast MRI (PC\u2010MRI) to measure the pulsatility of cerebral perforating arteries at 7\u2009T.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty participants, including 12 young volunteers and 8 elder adults, underwent high\u2010resolution 2D PC\u2010MRI scans with VENCs of 20\u2009cm\/s and 40\u2009cm\/s at 7T. The sensitivity of perforator detection and the reliability of pulsatility measurement of cerebral perforating arteries using dual\u2010VENC PC\u2010MRI were evaluated by comparison with the single\u2010VENC data. The effects of temporal resolution in the PC\u2010MRI acquisition and aging on the pulsatility measurements were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to the single VENCs, dual\u2010VENC PC\u2010MRI provided improved sensitivity of perforator detection and more reliable pulsatility measurements. Temporal resolution impacted the pulsatility measurements, as decreasing temporal resolution led to an underestimation of pulsatility. Elderly adults had elevated pulsatility in cerebral perforating arteries compared to young adults, but there was no difference in the number of detected perforators between the two age groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Dual\u2010VENC PC\u2010MRI is a reliable imaging method for the assessment of pulsatility of cerebral perforating arteries, which could be useful as a potential imaging biomarker of aging and cSVD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30073","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T08:48:41Z","timestamp":1709628521000},"page":"605-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Assessment of arterial pulsatility of cerebral perforating arteries using <scp>7T<\/scp> high\u2010resolution <scp>dual\u2010VENC<\/scp> phase\u2010contrast <scp>MRI<\/scp>"],"prefix":"10.1002","volume":"92","author":[{"given":"Jianing","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Biomedical Engineering Northwestern University  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3729-851X","authenticated-orcid":false,"given":"Soroush","family":"Heidari Pahlavian","sequence":"additional","affiliation":[{"name":"USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Joe","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Tereza","family":"Gamez","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0889-5629","authenticated-orcid":false,"given":"Tianrui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Biomedical Engineering Northwestern University  Evanston Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha J.","family":"Ma","sequence":"additional","affiliation":[{"name":"USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California  Los Angeles California USA"},{"name":"Siemens Medical Solutions USA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6357-9329","authenticated-orcid":false,"given":"Jin","family":"Jin","sequence":"additional","affiliation":[{"name":"USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California  Los Angeles California USA"},{"name":"Siemens Healthcare Pty Ltd  Brisbane Queensland Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven Yong","family":"Cen","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keck School of Medicine University of Southern California  Los Angeles California USA"},{"name":"Department of Radiology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helena C.","family":"Chui","sequence":"additional","affiliation":[{"name":"Department of Neurology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5173-7059","authenticated-orcid":false,"given":"Lirong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"},{"name":"Department of Biomedical Engineering Northwestern University  Evanston Illinois USA"},{"name":"USC Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine University of Southern California  Los Angeles California USA"},{"name":"Department of Neurology, Keck School of Medicine University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.01020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000007654"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70104-6"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X15606723"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-132606"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-015-2462-0"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16647396"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bpa.12224"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11936-017-0555-1"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1552-6569.2001.tb00039.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.120.016883","article-title":"Velocity Pulsatility and arterial distensibility along the internal carotid artery","volume":"9","author":"Tuijl RJ","year":"2020","journal-title":"J Am Heart Assoc"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27989"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28677"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A7450"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28062"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20927101"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3306"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26821"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27304"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/0730-725X(89)90399-8"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.665480"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.1910330119"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20171280"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0236049"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr253"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.642264"},{"key":"e_1_2_7_29_1","article-title":"Higher Pulsatility in cerebral perforating arteries in patients with small vessel disease related stroke, a 7T MRI study","volume":"50","author":"Geurts LJ","year":"2018","journal-title":"Stroke"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.25595"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24991"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.00961"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-022-09179-3"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16629486"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccb.2022.100143"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2022.858805"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2017.0430"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2022.12.005"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.30073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T19:59:51Z","timestamp":1717185591000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.30073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,5]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/mrm.30073"],"URL":"https:\/\/doi.org\/10.1002\/mrm.30073","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3,5]]},"assertion":[{"value":"2023-12-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}