{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T01:47:52Z","timestamp":1790473672790,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>T<jats:sub>1<\/jats:sub> mapping is a widely used quantitative MRI technique, but its tissue\u2010specific values remain inconsistent across protocols, sites, and vendors. The ISMRM Reproducible Research and Quantitative MR study groups jointly launched a challenge to assess the reproducibility of a well\u2010established inversion\u2010recovery T<jats:sub>1<\/jats:sub> mapping technique, using acquisition details from a seminal T<jats:sub>1<\/jats:sub> mapping paper on a standardized phantom and in human brains.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The challenge used the acquisition protocol from Barral et al. (2010). Researchers collected T<jats:sub>1<\/jats:sub> mapping data on the ISMRM\/NIST phantom and\/or in human brains. Data submission, pipeline development, and analysis were conducted using open\u2010source platforms. Intersubmission and intrasubmission comparisons were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighteen submissions (39 phantom and 56 human datasets) on scanners by three MRI vendors were collected at 3\u2009T (except one, at 0.35\u2009T). The mean coefficient of variation was 6.1% for intersubmission phantom measurements, and 2.9% for intrasubmission measurements. For humans, the intersubmission\/intrasubmission coefficient of variation was 5.9\/3.2% in the genu and 16\/6.9% in the cortex. An interactive dashboard for data visualization was also developed: \n<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/rrsg2020.dashboards.neurolibre.org\">https:\/\/rrsg2020.dashboards.neurolibre.org<\/jats:ext-link>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The T<jats:sub>1<\/jats:sub> intersubmission variability was twice as high as the intrasubmission variability in both phantoms and human brains, indicating that the acquisition details in the original paper were insufficient to reproduce a quantitative MRI protocol. This study reports the inherent uncertainty in T<jats:sub>1<\/jats:sub> measures across independent research groups, bringing us one step closer to a practical clinical baseline of T<jats:sub>1<\/jats:sub> variations in vivo.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30111","type":"journal-article","created":{"date-parts":[[2024,5,11]],"date-time":"2024-05-11T04:45:02Z","timestamp":1715402702000},"page":"1115-1127","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Repeat it without me: Crowdsourcing the T<sub>1<\/sub> mapping common ground via the ISMRM reproducibility challenge"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7726-4456","authenticated-orcid":false,"given":"Mathieu","family":"Boudreau","sequence":"first","affiliation":[{"name":"NeuroPoly Lab Polytechnique Montr\u00e9al  Montr\u00e9al Quebec Canada"},{"name":"Montreal Heart Institute  Montr\u00e9al Quebec 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