{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T03:13:14Z","timestamp":1780456394300,"version":"3.54.1"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T00:00:00Z","timestamp":1715299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005085","name":"Beijing Institute of Technology","doi-asserted-by":"publisher","award":["XSQD\u2010202213003"],"award-info":[{"award-number":["XSQD\u2010202213003"]}],"id":[{"id":"10.13039\/501100005085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["7242275"],"award-info":[{"award-number":["7242275"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62076247"],"award-info":[{"award-number":["62076247"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>This study aims to develop and evaluate a novel cardiovascular MR sequence, MyoFold, designed for the simultaneous quantifications of myocardial tissue composition and wall motion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MyoFold is designed as a 2D single breathing\u2010holding sequence, integrating joint T<jats:sub>1<\/jats:sub>\/T<jats:sub>2<\/jats:sub> mapping and cine imaging. The sequence uses a 2\u2010fold accelerated balanced SSFP (bSSFP) for data readout and incorporates electrocardiogram synchronization to align with the cardiac cycle. MyoFold initially acquires six single\u2010shot inversion\u2010recovery images, completed during the diastole of six successive heartbeats. T<jats:sub>2<\/jats:sub> preparation (T<jats:sub>2<\/jats:sub>\u2010prep) is applied to introduce T<jats:sub>2<\/jats:sub> weightings for the last three images. Subsequently, over the following six heartbeats, segmented bSSFP is performed for the movie of the entire cardiac cycle, synchronized with an electrocardiogram. A neural network trained using numerical simulations of MyoFold is used for T<jats:sub>1<\/jats:sub> and T<jats:sub>2<\/jats:sub> calculations. MyoFold was validated through phantom and in vivo experiments, with comparisons made against MOLLI, SASHA, T<jats:sub>2<\/jats:sub>\u2010prep bSSFP, and the conventional cine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In phantom studies, MyoFold exhibited a 10% overestimation in T<jats:sub>1<\/jats:sub> measurements, whereas T<jats:sub>2<\/jats:sub> measurements demonstrated high accuracy. In vivo experiments revealed that MyoFold T<jats:sub>1<\/jats:sub> had comparable accuracy to SASHA and precision similar to MOLLI. MyoFold demonstrated good agreement with T<jats:sub>2<\/jats:sub>\u2010prep bSSFP in myocardial T<jats:sub>2<\/jats:sub> measurements. No significant differences were observed in the quantification of left\u2010ventricle wall thickness and function between MyoFold and the conventional cine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MyoFold presents as a rapid, simple, and multitasking approach for quantitative cardiovascular MR examinations, offering simultaneous assessment of tissue composition and wall motion. The sequence's multitasking capabilities make it a promising tool for comprehensive cardiac evaluations in clinical settings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30124","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T09:44:40Z","timestamp":1715334280000},"page":"1064-1078","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<scp>MyoFold<\/scp>: Joint myocardial tissue composition and wall motion quantification via a highly folded sequence"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5188-6281","authenticated-orcid":false,"given":"Rui","family":"Guo","sequence":"first","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingwei","family":"Fan","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bowei","family":"Liu","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofeng","family":"Qian","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-5213-2000","authenticated-orcid":false,"given":"Jiahuan","family":"Dai","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0080-3052","authenticated-orcid":false,"given":"Dongyue","family":"Si","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Optics and Photonics Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ancong","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guozhao","family":"Dong","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongsheng","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases The Affiliated Hospital of Yan'an University  Shaanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Xiao","sequence":"additional","affiliation":[{"name":"Bio\u2010Med Informatics Research Center and Clinical Research Center, Xinqiao Hospital Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Ding","sequence":"additional","affiliation":[{"name":"Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine Tsinghua University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoying","family":"Tang","sequence":"additional","affiliation":[{"name":"School of Medical Technology Beijing Institute of Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-309077"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.05.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-017-0389-8"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20110"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-11-56"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-021-00823-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.054432"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcvm.2022.953823"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25975"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29170"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27466"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28753"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-014-0102-0"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25402"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.28321"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26216"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11971"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.08.028"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2020.02.005"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2019.08.008"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27474"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-018-0217-y"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27935"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24878"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29782"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmrb.1994.1048"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20835"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2009.2035616"},{"key":"e_1_2_7_30_1","volume-title":"Proceedings of the 32nd Annual Meeting of the ISMRM","author":"Qian X","year":"2023"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-16-2"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehx243"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.15801"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12968-021-00834-0"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.27555"},{"key":"e_1_2_7_36_1","article-title":"Landmark detection in cardiac MRI by using a convolutional neural network. Radiol","volume":"3","author":"Xue H","year":"2021","journal-title":"Artif Intell."},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25258"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25458"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2012.06.010"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25377"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.29397"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.28739"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.1880070323"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.30124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T04:22:54Z","timestamp":1719202974000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.30124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,10]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,9]]}},"alternative-id":["10.1002\/mrm.30124"],"URL":"https:\/\/doi.org\/10.1002\/mrm.30124","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,10]]},"assertion":[{"value":"2023-10-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-05-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}