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Imaging was repeated in 34 subjects at total lung capacity (TLC). Regional maps of the fractions of dissolved xenon in red blood cells (RBC), membrane (M), and airspace (Gas) were acquired at an isotropic resolution of 2\u2009cm, from which global averages of the ratios RBC:M, RBC:Gas, and M:Gas were computed.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Data from 26 males and 36 females with a median age of 43\u2009y (range: 20\u201369\u2009y) were of sufficient quality to analyze. Age (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0006) and sex (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.0001) were significant predictors for RBC:M, and a linear regression showed higher values and steeper decline in males: RBC:M(Males)\u2009=\u2009\u22120.00362\u2009\u00d7\u2009Age\u2009+\u20090.60 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.01,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.25); RBC:M(Females)\u2009=\u2009\u22120.00170\u2009\u00d7\u2009Age\u2009+\u20090.44 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02,\n                      <jats:italic>R<\/jats:italic>\n                      <jats:sup>2<\/jats:sup>\n                      \u2009=\u20090.15). Similarly, age and sex were significant predictors for RBC:Gas but not for M:Gas. RBC:M, M:Gas and RBC:Gas were significantly lower at TLC than at FRC (plus inhaled volume), with an average 9%, 30% and 35% decrease, respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Expected age and sex dependence of pulmonary function concurs with\n                      <jats:sup>129<\/jats:sup>\n                      Xe RBC:M imaging results, demonstrating that these variables must be considered when reporting Xe\u2010MRI metrics. Xenon doses and breathing maneuvers should be controlled due to the strong dependence of Xe\u2010MRI metrics upon lung volume.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mrm.30133","type":"journal-article","created":{"date-parts":[[2024,5,10]],"date-time":"2024-05-10T03:44:50Z","timestamp":1715312690000},"page":"1471-1483","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Age, sex, and lung volume dependence of dissolved xenon\u2010129 MRI gas exchange metrics"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1874-4775","authenticated-orcid":false,"given":"Guilhem J.","family":"Collier","sequence":"first","affiliation":[{"name":"POLARIS, Division of Clinical Medicine School of Medicine &amp; Population Health, University of Sheffield  Sheffield UK"},{"name":"Insigneo Institute, University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie J.","family":"Smith","sequence":"additional","affiliation":[{"name":"POLARIS, Division of Clinical Medicine School of Medicine &amp; Population Health, University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1080-9861","authenticated-orcid":false,"given":"Laura C.","family":"Saunders","sequence":"additional","affiliation":[{"name":"POLARIS, Division of Clinical Medicine School of Medicine &amp; Population Health, University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Swift","sequence":"additional","affiliation":[{"name":"POLARIS, Division of Clinical Medicine School of Medicine &amp; Population Health, University of Sheffield  Sheffield UK"},{"name":"Insigneo Institute, University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Marshall","sequence":"additional","affiliation":[{"name":"POLARIS, Division of Clinical Medicine School of Medicine &amp; Population Health, University of Sheffield  Sheffield UK"},{"name":"Insigneo Institute, University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8358-394X","authenticated-orcid":false,"given":"Neil J.","family":"Stewart","sequence":"additional","affiliation":[{"name":"POLARIS, Division of Clinical Medicine School of Medicine &amp; Population Health, University of Sheffield  Sheffield UK"},{"name":"Insigneo Institute, University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4108-9035","authenticated-orcid":false,"given":"Graham","family":"Norquay","sequence":"additional","affiliation":[{"name":"POLARIS, Division of Clinical Medicine School of Medicine &amp; Population Health, University of Sheffield  Sheffield UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7979-5840","authenticated-orcid":false,"given":"Paul J. 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