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Faster blood flow could lead to a bolus duration shorter than the applied PLD of VSASL and cause underestimation of cerebral blood flow (CBF). This study aims to evaluate the performance of velocity\u2010selective inversion (VSI) prepared arterial spin labeling (ASL) with different PLDs and pseudo\u2010continuous ASL (PCASL) for quantification of hypercapnia\u2010induced cerebrovascular reactivity (CVR), using phase\u2010contrast (PC) MRI as a global reference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We compared CVR obtained by VSI\u2010ASL with PLD of 1520\u2009ms (VSASL\u20101520), 1000\u2009ms (VSASL\u20101000), and 500\u2009ms (VSASL\u2010500), PCASL with PLD of 1800\u2009ms (PCASL\u20101800), and PC MRI on eight healthy volunteers at two sessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with PC MRI, VSASL\u20101520 produced significantly lower global CVR values, while PCASL\u20101800, VSASL\u20101000, and VSASL\u2010500 yielded more consistent results. The reduced CVR in VSASL\u20101520 was more pronounced in carotid territories including frontal and temporal lobes than in vertebral territories such as the occipital lobe. This is largely caused by the underestimated perfusion during hypercapnia due to the reduced bolus duration being less than the PLD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although VSASL offers certain advantages over spatially selective ASL due to its reduced susceptibility to delayed ATT, this technique is prone to biases when the ATT is excessively short. Therefore, a short PLD should be employed for reliable perfusion and CVR quantification in populations or conditions with fast flow.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30166","type":"journal-article","created":{"date-parts":[[2024,6,9]],"date-time":"2024-06-09T18:19:43Z","timestamp":1717957183000},"page":"2065-2073","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluating cerebrovascular reactivity measured by velocity selective inversion arterial spin labeling with different post\u2010labeling delays: The effect of fast flow"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7958-3787","authenticated-orcid":false,"given":"Feng","family":"Xu","sequence":"first","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University   Baltimore Maryland USA"},{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuimei","family":"Xu","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University   Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0940-1519","authenticated-orcid":false,"given":"Dan","family":"Zhu","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University   Baltimore Maryland USA"},{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-3202","authenticated-orcid":false,"given":"Dapeng","family":"Liu","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University   Baltimore Maryland USA"},{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute  Baltimore Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanzhang","family":"Lu","sequence":"additional","affiliation":[{"name":"The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University   Baltimore Maryland USA"},{"name":"F.M. 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