{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:50:18Z","timestamp":1792216218863,"version":"4.4.0"},"reference-count":64,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T00:00:00Z","timestamp":1719100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01NS100703"],"award-info":[{"award-number":["R01NS100703"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Differentiating ischemic brain damage is critical for decision making in acute stroke treatment for better outcomes. We examined the sensitivity of amide proton transfer (APT) MRI, a pH\u2010weighted imaging technique, to achieve this differentiation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a rat stroke model, the ischemic core, oligemia, and the infarct\u2010growth region (IGR) were identified by tracking the progression of the lesions. APT MRI signals were measured alongside ADC, T<jats:sub>1<\/jats:sub>, and T<jats:sub>2<\/jats:sub> maps to evaluate their sensitivity in distinguishing ischemic tissues. Additionally, stroke under hyperglycemic conditions was studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The APT signal in the IGR decreased by about 10% shortly after stroke onset, and further decreased to 35% at 5\u2009h, indicating a progression from mild to severe acidosis as the lesion evolved into infarction. Although ADC, T<jats:sub>1<\/jats:sub>, and T<jats:sub>2<\/jats:sub> contrasts can only detect significant differences between the IGR and oligemia for a portion of the stroke duration, APT contrast consistently differentiates between them at all time points. However, the contrast to variation ratio at 1\u2009h is only about 20% of the contrast to variation ratio between the core and normal tissues, indicating limited sensitivity. In the ischemic core, the APT signal decreases to about 45% and\u200933% of normal tissue level at 1\u2009h for the normoglycemic and hyperglycemic groups, respectively, confirming more severe acidosis under hyperglycemia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The sensitivity of APT MRI is high in detecting severe acidosis of the ischemic core but is much lower in detecting mild acidosis, which may affect the accuracy of differentiation between the IGR and oligemia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30194","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T06:53:53Z","timestamp":1719212033000},"page":"2140-2148","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Amide proton transfer <scp>MRI<\/scp> at 9.4 T for differentiating tissue acidosis in a rodent model of\u00a0ischemic stroke"],"prefix":"10.1002","volume":"92","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-3517","authenticated-orcid":false,"given":"Tao","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Radiology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jicheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1513-5181","authenticated-orcid":false,"given":"Julius","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. 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