{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:00:01Z","timestamp":1791216001962,"version":"4.1.0"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T00:00:00Z","timestamp":1724284800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01 EB028146"],"award-info":[{"award-number":["R01 EB028146"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01 EB029088"],"award-info":[{"award-number":["R01 EB029088"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Magnetic Resonance in Med"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Radiotherapy treatment planning (RTP) using MR has been used increasingly for the abdominal site. Multiple contrast weightings and motion\u2010resolved imaging are desired for accurate delineation of the target and various organs\u2010at\u2010risk and patient\u2010tailored planning. Current MR protocols achieve these through multiple scans with distinct contrast and variable respiratory motion management strategies and acquisition parameters, leading to a complex and inaccurate planning process. This study presents a standalone MR Multitasking (MT)\u2013based technique to produce volumetric, motion\u2010resolved, multicontrast images for abdominal radiotherapy treatment planning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The MT technique resolves motion and provides a wide range of contrast weightings by repeating a magnetization\u2010prepared (saturation recovery and T<jats:sub>2<\/jats:sub> preparations) spoiled gradient\u2010echo readout series and adopting the MT image reconstruction framework. The performance of the technique was assessed through digital phantom simulations and in vivo studies of both healthy volunteers and patients with liver tumors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the digital phantom study, the MT technique presented structural details and motion in excellent agreement with the digital ground truth. The in vivo studies showed that the motion range was highly correlated (R<jats:sup>2<\/jats:sup>\u2009=\u20090.82) between MT and 2D cine imaging. MT allowed for a flexible contrast\u2010weighting selection for better visualization. Initial clinical testing with interobserver analysis demonstrated acceptable target delineation quality (Dice coefficient\u2009=\u20090.85\u2009\u00b1\u20090.05, Hausdorff distance\u2009=\u20093.3\u2009\u00b1\u20090.72\u2009mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The developed MT\u2010based, abdomen\u2010dedicated technique is capable of providing motion\u2010resolved, multicontrast volumetric images in a single scan, which may facilitate abdominal radiotherapy treatment planning.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mrm.30256","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T18:57:35Z","timestamp":1724353055000},"page":"108-120","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Abdominal <scp>MR<\/scp> Multitasking for radiotherapy treatment planning: A motion\u2010resolved and multicontrast <scp>3D<\/scp> imaging approach"],"prefix":"10.1002","volume":"93","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8417-2819","authenticated-orcid":false,"given":"Junzhou","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Radiology University of Southern California   Los Angeles California USA"},{"name":"Department of Radiation Oncology University of Southern California  Los Angeles California USA"},{"name":"Department of Bioengineering University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9334-8684","authenticated-orcid":false,"given":"Anthony G.","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California  Los Angeles California USA"},{"name":"Biomedical Imaging Research Institute Cedars Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8532-9339","authenticated-orcid":false,"given":"Pei","family":"Han","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California  Los Angeles California USA"},{"name":"Biomedical Imaging Research Institute Cedars Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Southern California   Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Han","sequence":"additional","affiliation":[{"name":"Siemens Medical Solutions USA, Inc.  Malvern Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhehao","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Southern California   Los Angeles California USA"},{"name":"Department of Radiation Oncology University of Southern California  Los Angeles California USA"},{"name":"Department of Bioengineering University of California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nan","family":"Wang","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Han","sequence":"additional","affiliation":[{"name":"Biomedical Imaging Research Institute Cedars Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane C.","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric L.","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica E.","family":"Scholey","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5133-4903","authenticated-orcid":false,"given":"Sophia","family":"Cui","sequence":"additional","affiliation":[{"name":"Siemens Medical Solutions USA, Inc.  Malvern Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of California  Los Angeles California USA"},{"name":"Biomedical Imaging Research Institute Cedars Sinai Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensha","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology University of California  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-0260","authenticated-orcid":false,"given":"Zhaoyang","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Southern California   Los Angeles California USA"},{"name":"Department of Radiation Oncology University of Southern California  Los Angeles California USA"},{"name":"Department of Biomedical Engineering University of Southern California  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,22]]},"reference":[{"key":"e_1_2_7_2_1","unstructured":"DeVitaVT LawrenceTS RosenbergSA.DeVita Hellman and Rosenberg's Cancer: Principles & Practice of Oncology 10th Edition. Philadelphia Pennsylvania USA: Lippincott Williams & Wilkins."},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmra1608986"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20160406"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4758068"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/aaaca4"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.26271"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13014\u2010017\u20100854\u20104"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox006"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.20160667"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctro.2019.04.007"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2018.12.011"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/aa9517"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2016.10.006"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.4896096"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/aae56d"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2012.12.014"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3658737"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2015.01.035"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25753"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.26206"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.25665"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ab554a"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1109\/tmi.2021.3112818"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/rli.0000000000000381"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551\u2010018\u20100217\u2010y"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1088\/1361\u20106560\/ac783e"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.24602"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/mp.12139"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24564"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1109\/msp.2010.936030"},{"key":"e_1_2_7_32_1","volume-title":"Digital Image Processing","author":"Gonzalez R"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1118\/1.3480985"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27545"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.media.2014.08.003"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27200"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.24766"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1109\/tmi.2016.2610583"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.27553"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prro.2017.11.005"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2022.101020"}],"container-title":["Magnetic Resonance in Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mrm.30256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T19:09:37Z","timestamp":1730142577000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mrm.30256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,22]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/mrm.30256"],"URL":"https:\/\/doi.org\/10.1002\/mrm.30256","archive":["Portico"],"relation":{},"ISSN":["0740-3194","1522-2594"],"issn-type":[{"value":"0740-3194","type":"print"},{"value":"1522-2594","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,22]]},"assertion":[{"value":"2024-04-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}